Collaborative Research: Redox Behavior of Heme-NOx Models - A Vehicle for Outreach and Discovery

化学系的化学合成计划支持俄克拉荷马大学和南伊利诺伊大学爱德华兹维尔分校的Richter-Addo和Shaw小组之间的合作研究。这项研究使用先进的电化学技术来探索以氮氧化物为配体的血红素模型的氧化还原和化学行为。考察了氮氧化物配体对金属卟啉氧化还原行为的影响，以及卟啉骨架和反式配体对金属结合的NO基团化学反应活性的影响。光谱电化学，使用同步计时吸收和计时安培技术，将被用来得出不稳定的氧化还原中间体的UV-Vis光谱，以帮助对其进行表征。氮氧化物存在于城市大气和生活系统中。金属中心，如金属卟啉中的那些作为血红素模型存在的中心，调节着这些氮氧化物的化学。这个项目将深入了解新合成的以氮氧化物为配体的络合物的化学和氧化还原行为。子项目的不同复杂性是OU-SIUE合作的理想选择，因为它为博士生(OU)和瑞瑞(SIUE)的学生提供了合适的培训。将加强与少数群体服务机构的教育互动，并将为OU和SIUE的向上发展计划做出富有成效的贡献。

The Chemical Synthesis Program of the Division of Chemistry supports the collaborative research between the Richter-Addo and Shaw groups at the University of Oklahoma and Southern Illinois University Edwardsville, respectively. This research employs advanced electrochemistry techniques to probe the redox and chemical behavior of heme models bearing nitrogen oxides as ligands. Also investigated are the effects that nitrogen oxide ligands have on metalloporphyrin redox behavior, and the effects of the porphyrin scaffold and the trans ligands have on the chemical reactivity of the metal-bound NO groups. Spectroelectrochemistry, using simultaneous chronoabsorptometry and chronoamperometry techniques, will be utilized to derive the UV-vis spectra of unstable redox intermediates to aid in their characterization. Nitrogen oxides are present in the urban atmosphere and in living systems. Metal centers, such as those present in metalloporphyrins as heme models, regulate the chemistry of these nitrogen oxides. This project will shed insight on both the observed chemistry and redox behavior of newly synthesized complexes containing nitrogen oxides as ligands. The varied complexity of the sub-projects is ideal for the OU-SIUE collaboration, as it provides training appropriate for students at both a Ph.D. institution (OU) and an RUI (SIUE). Educational interactions with a minority-serving institution will be strengthened, as will productive contributions to the Upward Bound programs at both OU and SIUE.