MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance Spectrometer (NMR)

阿巴拉契亚州立大学的Alexander Schwab教授和他的同事Grant Holder、Nicole Bennett、Michael Ramey和Michael Hamburger将获得这一重大研究仪器计划颁发的这一奖项，他们将获得一台400 MHz的核磁共振波谱仪。该建议旨在加强各级的研究、培训和教育，特别是在下列领域：(A)调查利用稳定的叶立德的Wittig反应是否存在动力学微波效应；(B)生物膜中有机阴离子转运体的结构；(C)钴双(乙二酮肟)络合物作为制氢的可逆催化剂；(D)利用核磁共振氢谱和多元分析对含抗氧化剂原料进行代谢筛选；(E)多功能六苯；和(F)金属配位聚合物网络的模块化方法。核磁共振光谱是化学家可以用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为阿巴拉契亚州立大学教学和研究的组成部分。

With this award from the Major Research Instrumentation Program, Professor Alexander Schwab from Appalachian State University and colleagues Grant Holder, Nicole Bennett, Michael Ramey and Michael Hambourger will acquire a 400 MHz NMR spectrometer. The proposal is aimed at enhancing research training and education at all levels, especially in areas such as (a) investigation to probe whether there is a kinetic microwave effect utilizing the Wittig reaction of stabilized ylides; (b) structure of the organic anion transporter in biological membranes; (c) cobalt bis(glyoxime) complexes as reversible catalysts for hydrogen production; (d) metabolic screening of antioxidant-bearing raw materials using 1H NMR and multivariate analysis; (e) multifunctional hexaphenylbenzenes; and (f) modular approach to metal coordination polymer networks.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research at Appalachian State University.