MRI: Acquisition of a 400 MHz NMR Spectrometer to Enhance Undergraduate and Faculty Research

卡尼修斯学院的Mary O‘Sullivan教授及其同事Mariusz Kozik、Timothy Gregg、Jeremy Steinbacher和Sarah Evans将获得这一重大研究仪器项目的奖项，他们将获得一台400 MHz的核磁共振波谱仪。该建议旨在加强各级的研究、培训和教育，特别是在下列领域：(A)开发用于氟核磁共振成像的颗粒型造影剂；(B)有机机理和方法的研究(丙二烯环丙化)；(C)开发寄生虫中一种酶的抑制剂(锥虫硫酮还原酶)；(D)多胺与N-甲基-D-天冬氨酸(NMDA)受体的相互作用研究；(E)DNA-蛋白质交联链的研究；(F)阐明无机络合物结构的研究(过渡金属取代杂多钨酸盐)；以及(G)无机络合物作为光活化催化剂用于还原反应。核磁共振光谱是化学家可用于阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为卡尼修斯学院和邻近机构教学和研究的组成部分。

With this award from the Major Research Instrumentation Program, Professor Mary O'Sullivan from Canisius College and colleagues Mariusz Kozik, Timothy Gregg, Jeremy Steinbacher and Sarah Evans will acquire a 400 MHz NMR spectrometer. The proposal is aimed at enhancing research training and education at all levels, especially in areas such as (a) development of particle-based contrast agents for fluorine MRI; (b) investigations of organic mechanisms and methodologies (allene cyclopropanation); (c) development of inhibitors of an enzyme (trypanothione reductase) in parasites; (d) studies of the interactions of polyamines with the N-methyl-D-aspartate (NMDA) receptor; (e) investigations of DNA-protein cross-links; (f) studies to elucidate the structures of inorganic complexes (transition-metal substituted heteropolytungstates); and (g) uses of inorganic complexes as photo-activated catalysts for reduction reactions.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research at Canisius College and neighboring institutions.