MRI: Acquisition of Integrated Research Instrument for Large Animal Testing Investigation

摘要Sankar 1229392这项提案要求为适用于大型动物测试和生物植入材料表征的仪器提供资金。他们正在特别考虑一种具有XRF功能的HR微型CT和一种多光子共聚焦显微镜。这两个片段被串联使用，以完整地呈现全身动物模型。所要求的能力将使动物的显微手术、活体实时3D监测和活体成像成为可能，以评估深层组织。植入物的设计将在需要时提供最佳治疗，并在不再需要时进行生物溶解。这种创新将特别有利于儿童腭裂患者、长骨的角度畸形、肢体长度不一致或创伤，包括需要针头和螺丝钉进行修复的骨折。其他应用领域包括婴儿潮一代老年患者的骨质疏松性脆性骨折(手腕、髋部和脊柱)和多发性肋骨骨折的重建(创伤)。

ABSTRACT Sankar 1229392This proposal is requesting funding for instrumentation suitable for 'large' animal testing and characterization of bio-implant materials. They are specifically considering a HR micro-CT with XRF feature and a multi-photon confocal microscope. These two pieces are used in tandem to completely image whole bady animal models. The requested capability will enable Micro-surgery in animals, in vivo real-time 3D monitoring and in vivo imaging, for evaluating deep tissue. The implants will be designed to provide optimum therapy when required and to bio-dissolve when no longer needed. Such innovations would particularly benefit pediatric cleft palate patients, angular deformities of long bones, limb length discrepancies, or trauma including fractures that require pins and screws for repair. Other areas of application include osteoporotic fragility fractures in aging baby boomers (wrist, hip and spine) and reconstruction of multiple rib fractures (trauma).