Collaborative Research: Stepwise Functionalization and Surface Modification for ZnO Nanostructure-based Biosensors

1264508（Lu）拟议研究的目标是对纳米结构ZnO和MgZnO以及生物分子的表面和界面化学进行深入的科学理解，以便在分子水平上设计和开发创新的表面功能化，以实现新一代具有超高灵敏度和选择性以及多模式操作的生物传感器。这项多学科研究将包括ZnO和MgZnO纳米结构的MOCVD生长与控制的尺寸和形态，分子连接层的化学结合的设计和实验，ZnO/有机分子界面的综合表征，以及传感应用的功能化技术的实施。主要的研究方法包括：（1）合成具有可控尺寸、形貌和表面润湿性的高度有序的ZnO和MgZnO纳米结构;（ii）研究这些纳米结构与通过使用探针发色团设计的分子连接层之间的物理和化学性质，以实现对界面化学的前所未有的理解，及（iii）实施界面化学以设计及开发应用于ZnO纳米结构生物传感器的表面功能化技术。一般公开声明：本项目将研究如何将在传感器开发中重要的分子（例如抗体或酶）固定在纳米材料上。 确保生物分子在固定化后良好地发挥功能是成功开发生物传感器的关键，该提议将开发新的固定化策略。

1264508(Lu) The goal of the proposed research is to perform in-depth scientific understanding of surface and interface chemistry of nanostructured ZnO and MgZnO and biomolecules in order to design and develop the innovative surface functionalization at the molecular level to enable a new generation of biosensors with ultra-high sensitivity and selectivity, and multi-modal operation. This multidisciplinary research will include MOCVD growth of ZnO and MgZnO nanostructures with controlled dimension and morphology, design and experiments of chemical binding of molecular linker layers, comprehensive characterization of the ZnO/organic molecule interfaces, and implementation of the functionalization technology for sensing applications. The main approach includes (i) synthesis of highly ordered ZnO and MgZnO nanostructures with controlled dimension, morphologies, and surface wettability; (ii) Study of the photophysical and chemical properties between these nanostructures and the molecular linker layers designed by using the probe chromophores to achieve unprecedented understanding of the interfacial chemistry, and (iii) Implementation of the interfacial chemistry to design and develop the surface functionalization technology for application in the ZnO nanostructure-based biosensors.General public statement:This project will study how molecules important in sensor development, for example antibodies or enzymes, may be immobilized on nanomaterials. Ensuring that biomolecules function well after immobilization is critical to the successful development of biosensors and this proposal will develop new immobilization strategies.