AgriSense: Multichannel disposable sensors for animal health disease diagnostics

1264705（Vogel）。快速和灵敏地检测牛呼吸道疾病（BRD）相关的病毒感染的活动物被认为是关键，以尽量减少这种疾病的影响。目前，最常用的血清学诊断方法是荧光标记的ELISA。基于ELISA的测试是有限的，因为它通常依赖于每个ELISA板的单个测试样品中的单个病毒抗体亚型的检测，测试相对缓慢（长达1周）且昂贵（每次测试约5美元）。一个低成本的多重平台，能够检测几个抗体标记物相关的BRD感染在同一测试测定将提供显着的经济效益，为常规血清学检测。此外，快速农场？cowside？多重诊断能力将是朝着更高效和有效管理、控制和/或根除BRD相关病原体迈出的重要一步。目前，没有用于动物卫生部门的商业疾病诊断的电子场测试，更不用说BRD了。 我们的团队将通过构建廉价的电化学传感器来检测与BRD感染相关的生物标志物来应对这些挑战。

1264705(Vogel). Rapid and sensitive detection of bovine respiratory disease (BRD)-associated viral infections in live animals is recognized as key to minimizing the impact of this disease. Currently, the most common method of serological diagnosis is fluorescently labeled ELISAs. ELISA-based testing is limited as it typically relies on the detection of a single viral antibody subtype within an individual test sample per ELISA plate, the testing is relatively slow (up to 1 week) and expensive (~$5 per test). A low-cost multiplexed platform capable of detecting several antibody markers related to BRD infections in the same test assay would offer significant economic benefits for routine serological testing. Additionally, rapid on-farm ?cowside? multiplexed diagnostic capabilities would be a major step forward towards more efficient and effective management, control and/or eradication of BRD-associated pathogens. At present there is no electronic field based test for disease diagnostics available commercially for the animal health sector, let alone for BRD. Our team will address these challenges by building inexpensive electrochemical sensors for detection of biomarkers associated with BRD infection.