Enhancing Bioanalytical Applications of nanoGUMBOS

在化学系化学测量和成像项目以及化学、生物工程、环境和运输系统（CBET）系纳米生物传感项目的支持下，路易斯安那州立大学农业与机械学院的Isiah Warner、Daniel Hayes和Francisco Hung教授及其团队将优化从一组基于有机盐的均匀材料（GUMBOS）中提取的新型纳米材料的开发。本研究的目的是将这些纳米umbos应用于测量科学。这些材料可以被开发为安全有效的替代目前用于生物分析应用的许多纳米材料。本研究旨在研究纳米ogumbos的特性，这些特性有助于其稳定性、可调性、生物相容性以及在此类应用中的适用性。因此，本提案概述了纳米ogumbos通过独特的阳离子和阴离子组合来有效组合性能的潜力。作为一个例子，荧光纳米颗粒可以通过使用荧光染料作为阳离子和传统阴离子从GUMBOS生成。此外，非荧光磁性颗粒可通过使用非荧光阳离子与顺磁性阴离子结合而产生。显然，对于给定的nanoGUMBOS，可以通过类似策略的组合来实现多种特性。这样的粒子将具有统一的多种功能，从而实现纳米材料在每给定表面体积比的最大表面活性方面的全部潜力。这与许多纳米颗粒形成对比，在这些纳米颗粒中，通过将具有这些特性的物质独立注入到中性物质（如二氧化硅）中，可以产生多种功能。华纳教授和他的团队一直积极参与教育策略，利用研究和指导作为工具，积极吸引本科生参与科学、技术、工程和数学（STEM）教育。他们将继续努力吸引不同背景的本科生和研究生参与这项资助。

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry and the Nano-Biosensing Program in the Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET), Professors Isiah Warner, Daniel Hayes, and Francisco Hung at Louisiana State University & Agricultural and Mechanical College and their groups will optimize development of novel nanomaterials derived from a group of uniform materials based on organic salts (GUMBOS). The goal of this research is to apply these nanoGUMBOS toward applications in measurement science. These materials can be developed as safe and effective alternatives to many current nanomaterials used for bioanalytical applications. This research is designed to examine the properties of nanoGUMBOS that contribute to their stability, tunability, biocompatibility, and ready applicability for use in such applications. Thus, the potential of nanoGUMBOS for employing effective combinations of properties through unique combinations of cations and anions is outlined in this proposal. As an example, a fluorescent nanoparticle may be generated from GUMBOS by use of a fluorescent dye as the cation and a traditional anion. In addition, a non-fluorescent magnetic particle may be generated by use of a non-fluorescent cation in combination with a paramagnetic anion. Obviously, multiple properties for a given nanoGUMBOS can be achieved through a combination of similar strategies. Such particles would then have uniform multiple functionalities and thus realize the full potential of nanomaterials in terms of maximum surface activity per given surface to volume ratio. This is in contrast to many nanoparticles where multiple functionalities are generated by independently injecting species with these properties into a neutral species such as silica.Professor Warner and his team have been actively involved in educational strategies for using research and mentoring as tools to actively engage undergraduates in science, technology, engineering, and mathematics (STEM) education. They will continue their efforts in engaging undergraduate and graduate students of diverse backgrounds in this grant.