Aligned Core-Shell Piezoelectric Nanofibers based Pressure Sensors on Catheter

本研究的目的是通过功能性纳米材料和柔性微系统的集成，开发一种新型的微型化导管传感器技术，用于原位血压和流量监测，具有高灵敏度，快速恢复时间和微创性。特别是，我们将开发高度对齐的核-壳piezoelectricnanofibers为基础的柔性薄膜传感器图案的导管tips与dramatallyreduced形状因子，这是准备部署在intravascular environment.Intellectual优点：实时血管内压力测量技术是至关重要的血流动力学，这表明心血管系统的生理状态进行评估。我们提出了一个范式转变，在设计血管内压力传感技术，通过开发薄膜柔性传感结构，使用纳米工程压电聚合物，可以集成在导管上，而不消耗其内腔空间。更广泛的影响：开发具有内置纳米结构作为核心传感元件的多功能微传感器可以深刻地改变导管的开发。此外，从这项研究中产生的技术可以扩展到开发广泛的灵活，稳健和生物相容的传感纳米材料，这些材料具有紧急行为，可以非常有效地量化生物过程。

The objective of this research is to develop a new class of miniaturized sensors-on-cathetertechnology through the integration of functional nanomaterials and flexible microsystems, forin situ blood pressure and flow monitoring with high sensitivity, fast recovery time andminimal invasiveness. In particular, we will develop highly aligned core-shell piezoelectricnanofibers based flexible thin film sensors patterned on catheter tips with dramaticallyreduced form factor, which are ready to be deployed in intra-vascular environment.Intellectual Merits: Real-time endovascular pressure measurement techniques are crucial to evaluate the hemodynamics, which indicates the physiological state of the cardiovascular system. We propose a paradigm shift in designing the endovascular pressure sensing technology, through developing thin film flexible sensing structures using nanoengineered piezoelectric polymers which can be integrated on catheters without consuming its internal lumen space. Broader Impact: Development of versatile microsensors with built-in nanostructures as the core sensing elements can profoundly revolutionize the catheter development. In addition, the technology generated from this research can be extended to develop a broad class of flexible, robust, and biocompatible sensing nanomaterials with emergent behavior that work with the extraordinary effectiveness to quantify the biological processes.