MRI: Acquisition of a 400 MHz NMR Spectrometer - A Vital Instrument to Sustain and Enhance Research and Scholarship at St. Cloud State

在重大研究仪器计划(MRI)的这一奖项和化学研究仪器计划(CRIF)的支持下，圣克劳德州立大学的Latha Ramakrishnan教授及其同事Tamara Leenay、Mohammad Mahroof-Tahir和Mark Mechelke将获得一台400 MHz核磁共振光谱仪。这种光谱仪将允许在各种领域进行研究，例如研究与生物相关的物种。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将是圣克劳德州立大学本科生和邻近机构(如北亨内平社区学院)以及当地和地区工业进行的教学和研究的重要组成部分。该奖项旨在加强各级的研究和教育，特别是在以下领域：(A)研究基本的生化原理，如主要的抑制性和兴奋性神经通讯系统的功能和作用机制；(B)研究天然产物对癌细胞的毒性机制；(C)研究钒配合物的结构-性质，即物理、化学和电子关系，以破译其潜在的抗糖尿病机理；以及(D)研究环Mannich碱的细胞毒性机理。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Latha Ramakrishnan from St. Cloud State University and colleagues Tamara Leenay, Mohammad Mahroof-Tahir and Mark Mechelke will acquire a 400 MHz NMR spectrometer. This spectrometer will allow research in a variety of fields such as the study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research performed by undergraduate students at St. Cloud State University and neighboring institutions such as North Hennepin Community College as well as local and regional industries.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) investigating fundamental biochemical principles such as the function and mechanism of action of major inhibitory and excitatory neural communication systems in flatworms; (b) studying the mechanism of toxicity of natural producs towards cancer cells; (c) investigating structure-properties, i.e., physical, chemical, and electronic relationships of vanadium complexes to decode their potential anti-diabetic mechanisms; and (d) studying the mechanism of cytotoxicity of cyclic Mannich bases.