MRI: Acquisition of A Versatile High Resolution MS System for Determination of Small Molecules of Environmental and Health Concern

PI: Reckhow, David A.提案：1428873标题：MRI：用于确定环境和健康问题小分子的多功能高分辨率MS系统的获取该提案用于获取用于识别和量化水中痕量有机污染物的高分辨率系统。参与该项目的研究小组在环境工程和公共卫生之间建立了牢固的联系。他们提出的研究项目有许多应用目标，包括潜在的转化效益，例如发现和补救饮用水中新出现的污染物，以及第三世界国家的水和卫生设施的新治疗方法。Xevo G2-S QTof由于其简单直观的界面，非常适合来自广泛背景的学生使用。该仪器将成为开放资源（EEAP）的核心，不仅对马萨诸塞大学的学生开放，而且对整个东北地区开放。在麻省理工学院，它将服务于环境工程的核心研究人员，以及不同科学学科和公共卫生的跨学科研究小组。在马萨诸塞大学之外，它将可供5所学院联盟的研究人员使用，尤其是新英格兰和附近州的大学和学院。技术描述该提案是为了获得用于识别和定量水中痕量有机污染物的高分辨率系统。Xevo G2-S QTof是一种四极杆飞行时间仪器，能够在液体（如UPLC）和气体（如GC）源之间快速切换。该仪器将成为开放资源（EEAP）的核心，不仅对马萨诸塞大学的学生开放，而且对整个东北地区开放。这一工具将有助于将工程管理和控制技术与公共卫生的最终终端联系起来。例如，流域管理和处理技术对饮用水中卤苯并苯醌和相关化合物引起的膀胱癌的作用。另一份报告涉及工业活动中溴化物含量升高对癌症的作用。第三个问题涉及地表水中由藻类活动和光作用反应产生的含氮有机化合物以及人类健康问题。其他公司则采用创新的混合藻-细菌颗粒来处理废水并生产生物燃料，或者采用生物电气系统来促进现代非冲洗系统中废水的处理，同时发电。

PI: Reckhow, David A.Proposal: 1428873Title: MRI: Acquisition of A Versatile High Resolution MS System for Determination of Small Molecules of Environmental and Health ConcernSignificanceThis proposal is for the acquisition of a high resolution system for identifying and quantifying trace organic contaminants in water. The research group involved in this project has forged a strong link between environmental engineering and public health. Their proposed research projects have many applied objectives including potential translational benefits, such as discovery and then remediation of emerging contaminants in drinking water, and novel treatments for water and sanitation in Third World countries. The Xevo G2-S QTof is ideally suited for use by students from broad backgrounds due to its simple and intuitive interface. This instrument will be a centerpiece of an open resource (EEAP) available not only to those at UMass, but across the Northeast region. At UMass, it will serve the core researchers in Environmental Engineering, as well as an interdisciplinary group of researchers in various science disciplines and Public Health. Outside of UMass, it will be available for use by researchers in the 5-college consortium, and beyond, especially Universities and Colleges in New England and nearby states. Technical DescriptionThis proposal is for the acquisition of a high resolution system for identifying and quantifying trace organic contaminants in water. The Xevo G2-S QTof is a quadrupole time-of-flight instrument capable of rapidly switching between liquid (e.g., UPLC) and gas (e.g., GC) sources. This instrument will be a centerpiece of an open resource (EEAP) available not only to those at UMass, but across the Northeast region. This instrument will help connect engineering management and control technologies to the ultimate endpoints of public health. Examples include the role of watershed management and treatment technologies on bladder cancer caused by halobenzoqinones and related compounds in drinking water. Another touches upon the role of elevated bromide from industrial activities on cancer. A third pertains to nitrogenous organic compounds generated in surface waters from algal activity and photonitration reactions and human health endpoints. Others employ innovative mixed algal-bacterial granules to treat wastewater and produce biofuel, or bioelectrical systems to facilitate wastewater treatment in modern non-flush systems while producing electricity.