MRI: Acquisition Of A Dual-Energy, 3-D X-Ray Microscope With Sub-Micron Resolution, Tunable Field Of View, and Phase Contrast

PI：Morgan，Elise F.Proposal：1429068标题：MRI：获得具有亚微米分辨率、可调视场和位相对比的双能三维X射线显微镜最近出现的三维X射线显微镜(XRM)是一种非破坏性成像手段，具有前所未有的多功能性，可用于多种类型的材料和结构的研究。新开发的XRM系统克服了旧系统的关键限制，包括样品大小和图像分辨率(固定视场)之间的严格权衡，无法合并从多个光束能量获得的图像数据，以及依赖吸收对比度作为唯一的成像模式。因此，XRM现在在工程和自然科学中的许多新的和多样化的应用中是可行的。本建议中要求提供资金的XRM文书非常适合促进研究与教育的融合。该仪器通过用户友好的软件和硬件界面生成丰富的数据集。这些数据包括高分辨率的3-D效果图、横断面图和定量结构测量，适用于多个层次的学生的研究项目和课堂作业。技术说明将使用该仪器的研究活动涉及生物力学、组织工程、骨骼和进化生物学、微流体学、地球科学、复杂流体和高温材料中的基本物理和生物现象。目前，这些研究活动使用多种方法来量化微观结构和成分，其中大多数是二维和/或破坏性的。所要求的XRM仪器将为这个现有的医疗机构增加一个新的和深刻的支持维度。该仪器通过用户友好的软件和硬件界面生成丰富的数据集。这些数据包括高分辨率的3-D渲染、横断面图和量化结构测量。

PI: Morgan, Elise F.Proposal: 1429068Title: MRI: Acquisition Of A Dual-Energy, 3-D X-Ray Microscope With Sub-Micron Resolution, Tunable Field Of View, and Phase ContrastSignificance3-D X-ray microscopy (XRM) has recently emerged as a non-destructive imaging modality with unprecedented versatility for study of numerous types of materials and structures. Newly developed XRM systems overcome key limitations of older systems, including the rigid trade-off between specimen size and image resolution (fixed field of view), inability to consolidate image data obtained from multiple beam energies, and reliance on absorption contrast as the only mode of imaging. As a result, XRM is now viable for a host of new and diverse applications in engineering and natural sciences. The XRM instrument for which funds are requested in this proposal is extremely well suited for fostering the integration of research and education. This instrument generates rich data sets via user-friendly software and hardware interfaces. These data, which include high-resolution 3-D renderings, cross-sectional views, and quantitative structural measures, are amenable to research projects and class assignments for students at multiple levels.Technical DescriptionThe research activities that will use this instrumentation address fundamental physical and biological phenomena in biomechanics, tissue engineering, skeletal and evolutionary biology, microfluidics, earth science, complex fluids, and high-temperature materials. Currently, these research activities use multiple methods, most of which are 2-D and/or destructive, to quantify microstructure and composition. The requested XRM instrument would add a new and profoundly enabling dimension to this existing armamentarium. This instrument generates rich data sets via user-friendly software and hardware interfaces. The data includes high-resolution 3-D renderings, cross-sectional views, and quantitative structural measures.