DMREF: Thin Film Biofabrication for Integrated Bio-electronics

1435957马里兰大学帕克·佩恩PIS建议通过开发通用的、基于生物的薄膜制造方法将生物功能融入电子设备中，将生物技术和微电子技术的进步整合在一起。薄水凝胶薄膜将被触发自组装，以响应当地施加的电信号。PI提出了将小分子、蛋白质和细胞结合到水凝胶膜中的方法，并将重点了解制造条件如何控制结构-性质-功能关系。提出了一种多层薄膜系统，它将允许生物和电子之间的通信。这项工作在四个方面具有潜在的变革性。首先，PI将应用生物学的进步作为材料科学的基础。第二，将理论和实验相结合来描述软物质的介观自组装。第三，电信号的空间、时间和数量精度将用于创建结构、赋予属性和执行功能。最后，生物技术和电子技术将被整合。建议加强国际合作，为学生提供参与跨越大陆和文化的项目的机会。拟议中的与工业合作伙伴的合作将加速将生物学纳入材料科学。投资促进机构还建议将这些活动纳入现有的大学与食品和药物管理局以及国家科学和技术研究所的伙伴关系。由于它们提供计量和监管指南，这些机构将是以生物为基础的材料引入市场的速度不可或缺的一部分。这些伙伴关系将有助于加快翻译速度，并为学生提供有意义的外部奖学金。

1435957University of Maryland College ParkPayneThe PIs propose to integrate advances in biotechnology and microelectronics by developing generic, biologically-based thin film fabrication methods to incorporate biological function into electronics. Thin hydrogel films will be triggered to self-assemble in response to locally-imposed electrical signals. The PIs propose methods to incorporate small molecules, proteins, and cells into the hydrogel films, and will focus on understanding how fabrication conditions control the structure-property-function relations. A multilayer thin film system is proposed that will allow communication between the biology and the electronics.The work is potentially transformative in four ways. First, the PIs will apply the advances in biology as an underpinning for materials science. Second, theory and experiments will be coupled to characterize the mesoscale self-assembly of soft matter. Third, the spatial, temporal and quantitative precision of electrical signals will be used to create structure, confer properties and perform functions. Finally, the biotechnology and electronics will be integrated.Strong international collaborations are proposed which will provide students with opportunities to participate in projects that span continents and cultures. The proposed collaboration with industrial partners will accelerate the incorporation of biology into materials science. The PIs also propose to integrate the activities within existing University partnerships with Food and Drug Administration and the National Institutes of Science and Technology. Because they provide the metrology and regulatory guidelines, these agencies will be integral to the speed that biologically-based materials are introduced into the marketplace. These partnerships will assist in accelerating translation and also in providing meaningful externships for students.