Collaborative Research: Planning Grant: I/UCRC for Advanced Mammalian Biomanufacturing Innovation Center (AMBIC)

约翰霍普金斯大学、克莱姆森大学和特拉华大学提议成立一个新的由美国国家科学基金会支持的工业/大学合作研究中心（I/UCRC），名为高级哺乳动物生物制造创新中心（AMBIC），以解决美国生物制药制造当前和未来面临的挑战。高级哺乳动物生物制造创新中心（AMBIC）将汇集领先的学术、工业和政府生物技术专家，目标是在竞争前的研究水平上推进细胞培养制造创新。AMBIC代表了一个独特的机会，通过汇集领先的研究人员和创新者来实施变革性的产品和工艺，从而解决美国生物制药制造中的技术挑战和瓶颈，这将导致一个更强大、更健康、更有竞争力的生物制药行业。通过这种方式，AMBIC将通过专注于哺乳动物细胞培养问题，成为保持国家生物制药生产卓越性的关键催化剂。AMBIC的三个重点是：1。哺乳动物基因组和细胞工程平台，目标是开发先进的平台，提高生产能力。具有获取任务的哺乳动物细胞组学和系统生物学？哺乳动物生产平台组学数据及性能实施标准优化生物反应器控制，以改善细胞性能，目标是表征代谢状态和实施先进的控制。该项目将支持计划会议，邀请生物制药行业和政府的合作伙伴参与AMBIC，并为该中心制定研究和教育计划。计划会议将有助于确定主要的研究挑战，并设计哺乳动物生物制造的前沿研究和教育计划。此外，AMBIC将建立和维持一个受过良好教育和积极进取的学生在生物制药制造和发展事业的各个层次的管道。与企业合作伙伴的合作将使学生能够解决行业面临的最紧迫的问题。此外，AMBIC将致力于吸引和激励来自代表性不足的少数民族的学生在生命科学、工程或相关STEM领域从事职业。通过系统生物学分析，新型细胞系开发和生物反应器优化，AMBIC将提供创新的解决方案，以提高生物制造效率。这些进步最终将有助于降低消费者的整体医疗保健成本，并使更多的患者能够负担得起并获得生物制药。

Johns Hopkins University, Clemson University, and the University of Delaware propose to form a new NSF-supported Industrial/University Cooperative Research Center (I/UCRC) entitled the Advanced Mammalian Biomanufacturing Innovation Center (AMBIC) to address current and future challenges faced by US bio-pharmaceuticals manufacturing. The Advanced Mammalian Biomanufacturing Innovation Center (AMBIC) will bring together leading academic, industrial, and government biotechnologists with the goal of advancing cell culture manufacturing innovation at a pre-competitive research level. AMBIC represents a unique opportunity to address technology challenges and bottlenecks in US biopharmaceutical manufacturing by bringing together leading researchers and innovators to implement transformative products and processes that will lead to a stronger, healthier, and more competitive biopharmaceutical industry. In this way, AMBIC will be a critical catalyst towards maintaining national excellence in biopharmaceutical production by focusing on mammalian cell culture issues. The three thrusts of AMBIC are as follows:1. Genome and Cellular Engineering of Mammalian Platform with the goal of developing advanced platforms with improved production capabilities.2.`Omics and Systems Biology for Mammalian Cells with the task of acquiring ?omics data and implementing standards of performance for the mammalian production platform3.Optimizing Bioreactor Control for Improved Cellular Performance with the objective of characterizing metabolic states and implementing advanced controls. This project will support the planning meeting to engage partners from the biopharmaceutical industry and government to participate in AMBIC and develop a research and educational program for the center. A planning meeting will help to identify major research challenges and to design a cutting edge research and educational program in mammalian biomanufacturing. Furthermore, AMBIC will establish and maintain a pipeline of educated and motivated students at all levels for careers in biopharmaceutical manufacturing and development. Collaborations with corporate partners will enable the students to work on the most pressing problems that the industry faces. In addition, AMBIC will serve to engage and excite students from under-represented minority populations to pursue a career in life sciences, engineering, or related STEM fields. Through systems biology analysis, novel cell line development, and bioreactor optimization, AMBIC will provide innovative solutions to improve biomanufacturing efficiencies. These advances will ultimately serve to lower overall health care costs for consumers and make biopharmaceuticals more affordable and available for a greater number of patients.