Novel coupling reactions

在这个由化学部化学催化项目资助的项目中，宾夕法尼亚大学的Patrick J. Walsh教授正在开发两个碳原子之间以及碳原子和硫原子之间形成键的新反应。这些元素之间的键存在于药物化合物、农产品和聚合物中，因此，拟议的研究有可能影响相应的科学和技术领域。总体目标是开发新的催化剂和催化过程，既合成有用的和实用的。沃尔什教授也在研究反应机制（即反应如何进行）和控制催化反应化学性质的因素，这将有助于优化催化结果，并增加我们的化学基础知识基础。沃尔什教授特别关注以下催化转化：1)亚砜阴离子的芳基化和二芳基亚砜的对映选择性合成，这在许多商业化药物中都有发现；2)亚砜亚胺的制备方法的发展，包括对映富集形式；3)引入一类新的有机催化剂，亚砜阴离子，它在许多C-C键形成反应中有潜在的应用。本研究的广泛影响在以下几个方面：1)本文介绍的新概念和新合成方法有望在学术界或工业界的中间体、药物、农产品或材料的制备中得到应用，对社会产生积极影响；2)本科学生正在获得化学研究的经验；3) PI向高中生讲授nsf支持的这项研究；4)PI通过出版物和大学研讨会以及会议传播这些调查结果；5)PI继续与墨西哥科学家开展国际科学合作推广计划。

In this project funded by the Chemical Catalysis Program of the Chemistry Division, Professor Patrick J. Walsh at the University of Pennsylvania is developing new reactions that form bonds between two carbon atoms and between a carbon atom and a sulfur atom. Bonds between these elements are found in pharmaceutical compounds, agricultural products, and polymers, and therefore, the proposed research has the potential to impact their corresponding scientific and technological areas. The overarching goal is to develop new catalysts and catalytic processes that are both synthetically useful and practical. Professor Walsh is also studying the reaction mechanisms (i.e., how the reactions work) and the factors that control the chemistry of the catalytic reactions, which will help to optimize the outcomes of the catalysis and to add to our fundamental knowledge base about chemistry. Prof. Walsh is specifically addressing the following catalytic transformations: 1) The arylation of sulfenate anions and the enantioselective synthesis of diarylsulfoxides, which are found in a number of commercialized medications, 2) the development of methods to prepare sulfoximines, including in enantioenriched form, and 3) the introduction of a new class of organocatalysts, sulfenate anions, which have potential applications in a number of C-C bond forming reactions. The broader impacts of this research are in the following areas: 1) The new concepts and synthetic methods introduced herein are expected to have a positive impact on society as they may find application in the preparation of intermediates, medications, agricultural products, or materials in academics or industry, 2) Undergraduate students are gaining experience in chemical research, 3) The PI lectures for high school students about this NSF-supported research 4) The PI disseminates the findings of these investigations by publication and seminars at universities and conferences, and 5) The PI continues an international scientific collaboration outreach program with Mexican scientists.