The role of palmitoylation in hair follicle and epidermal stem cell biology

蛋白质的活性可以通过糖、磷酸盐和脂质修饰来形成。 这项建议将调查的影响，脂质修饰称为棕榈酰化，我们知道的很少。 我们的初步实验表明，棕榈酰化对正常皮肤生物学至关重要。 我们将探索它对被修饰的蛋白质的生物学的影响，在其中发现它们的细胞和它们所在的组织。 更多地了解这些变化将有助于我们更多地了解我们皮肤的生物学，并有助于我们了解影响我们最大器官的疾病。

A proteins activity can be shaped by sugar, phosphate and lipid modifications. This proposal will investigate the effects of the lipid modification called palmitoylation, about which we know very little. Our preliminary experiments suggest that palmitoylation is crucial for normal skin biology. We will explore its effects on the biology of the proteins which are modified, the cells in which they are found and the tissues in which they reside. Understanding more about these modifications will help us to learn more about the biology of our skin and will help us to understand diseases which affect our largest organ.