Building a TERM Roadmap for Organ Disease, Washington, DC, March 16-17, 2015

在过去的十年里，研究小组在干细胞科学、组织和生物医学工程、低温保存和再生医学的其他领域取得了巨大的进展，并开始显示出有希望的结果。然而，对于器官疾病和损害，特别是心脏、肝脏、肺和肾脏等复杂器官，研究人员在很大程度上无法产生临床适用的解决方案。对器官损伤的解决方案的需求从未如此强烈。在过去的二十年里，器官等待名单迅速增长，而捐献者的数量却停滞不前。据估计，美国35%的死亡可以通过器官修复或移植来预防或显著延缓。需要新的解决方案来满足这一需求。研究人员建议进行景观分析研究和研讨会，以确定创造这些解决方案的关键里程碑。这项工作将为解决器官损伤创造一个关键路径路线图。这一路线图将包括纳入创新技术进步方法的具体机会，例如可用于补充、加强和利用传统研究资助的奖励和奖励。该研讨会将于2015年3月16日至17日在华盛顿特区举行，将召集来自学术界、工业界和政府机构的主要利益相关者。研究人员确定了本次研讨会的三个主要成果：(1)确定关键的定量里程碑，将在解决器官疾病的道路上开辟关键机会；(2)确定如何最好地识别拟议的研究途径或里程碑何时无法实现，以帮助将未来的研究计划集中在潜在的成功结果上；(3)利用激励性创新模式（奖励、挑战、奖励等）确定推进量化里程碑和补充或更好地针对现有研究资助计划的机会。研讨会确定了四个潜在里程碑的主题领域：法规、组织和生物医学工程、冷冻保存和生产/临床支持。在研讨会之前，将进行关键利益相关者访谈，以收集初步信息，确定这四次会议中每次会议的科学讨论内容。讲习班结束后，将提出并向公众传播有关推进器官疾病解决方案的路线图、里程碑和新方法的具体指南、里程碑和标准。

PI: Neubert, Josh Proposal Number: 1521828In the last decade, research groups have made great advances in stem cell science, tissue and biomedical engineering, cryopreservation, and other areas of regenerative medicine that have begun to show promising results. However, the ability to produce clinically applicable solutions to organ disease and impairment, especially in complex organs such as the heart, liver, lungs, and kidneys, has for the most-part eluded researchers. The need for solutions to organ impairment has never been greater. The organ waitlist has grown rapidly over the last two decades while the number of donors has stagnated. It is estimated that 35% of all U.S. deaths could be prevented or significantly delayed by organ repair or transplantation. New solutions are required to meet this demand. The investigators propose a landscape analysis study and workshop to identify key milestones toward creating these solutions. The work will create a critical-path roadmap toward solutions to organ impairment. Included in this roadmap will be specific opportunities to incorporate innovative methods for technology advancement such as prizes and awards that can be used to supplement, enhance, and leverage traditional research grants. The workshop will be hosted in Washington DC on March 16-17, 2015, convening key stakeholders from academia, industry, and government agencies. The investigators have defined three primary outcomes for this workshop: (1) Identify key quantitative milestones that will open critical opportunities on the road to solving organ disease; (2) Determine how to best identify when a proposed research avenue or milestone will not be achieved to help focus future research initiatives on potentially successful outcomes; and (3) Identify opportunities to advance quantitative milestones and supplement or better target existing research grant programs using incentivized innovation models (prizes, challenges, awards, etc.). Four topic areas of potential milestones have been identified for discussion during the workshop: Regulation, Tissue & Biomedical Engineering, Cryopreservation, and Manufacturing/Clinical support. Prior to the workshop, key stakeholder interviews will be conducted to gather preliminary information defining the content of the scientific discussions for each of these four sessions. Upon conclusion of the workshop, specific guidelines, milestones, and criteria will be presented and disseminated to the public concerning the roadmap, milestones, and new methodologies for advancing solutions to organ disease.