MRI: Acquisition of a 400 MHz NMR Spectrometer to Support Undergraduate Research and Chemical Education at Florida Gulf Coast University

在主要研究仪器计划(MRI)的这一奖项和化学研究仪器计划(CRIF)的支持下，佛罗里达墨西哥湾沿岸大学将获得一台400 MHz核磁共振光谱仪。该仪器将允许在不同领域进行研究，包括有机合成和材料、肽、法医和无机化学，并加强大学的教学计划。这项研究将影响生物和环境领域的兴趣，包括DNA稳定性、抗病毒多肽、新型药物的前体和气体吸附材料。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。该仪器将是佛罗里达墨西哥湾沿岸大学本科生进行的教学和研究的重要组成部分。核磁共振还将加强化学部门在药物鉴定方面与当地执法机构和本地生物技术公司合作的能力。建议的目的是加强所有层面的研究和教育，特别是在合成(A)生物启发离子液体；(B)与医学相关的天然产物；(C)生物活性分子；(D)研究膜破坏性抗病毒多肽的结构和功能；(E)研究核磁共振在DNA长期结构和化学稳定性方面的法医应用；以及(F)研究柱状离散结构中的金属-有机材料。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Florida Gulf Coast University will acquire a 400 MHz NMR spectrometer. The instrument will allow research in different areas including organic synthesis and materials, peptide, forensic and inorganic chemistry and enhance the teaching program at the University. The research will impact areas of biological and environmental interest including DNA stability, anti-viral peptides, precursors to novel drugs and gas adsorption materials. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument will be an integral part of teaching as well as research performed by undergraduate students at Florida Gulf Coast University. The NMR will also increase the chemistry department's capability to collaborate with local law enforcement institutions on drug identification as well as with local bio-tech companies.The proposal is aimed at enhancing research and education at all levels, especially in areas such as synthesizing (a) bio-inspired ionic liquids; (b) medicinally relevant natural products; (c) bioactive molecules; (d) studying structure and function of membrane disruptive anti-viral peptides; (e) studying forensic applications of NMR with concentration in long-term structural and chemical stability of DNA; and (f) studying metal-organic materials from pillared discrete structures.