TRR 134: Ingestive Behaviour: Homeostasis and Reward

肥胖的发病率和流行率持续上升，在食物空前丰富的人群中尤为明显。在此背景下，解开中枢神经机制是一项紧迫的任务，该机制整合了编码与食物选择和摄入相关的行为组合的稳态和奖励相关神经回路。基于在第一个资助期取得的重大和令人兴奋的进展，我们现在将扩大我们的概念方法和努力，系统地朝着更以系统为基础和转化研究计划的方向发展。为此，我们将定位我们的目标，在更广泛的背景下破译稳态和奖励回路之间的相互作用，涉及神经元和功能相互作用（水平a）。对这种串音的分析还将包括在更临床导向的翻译背景下的社会互动和线索触发/外部饮食行为的相关模型（B级）。将采用明确的干预策略，通过神经调节、药理手段或靶向神经外科方法来解决这些问题（C级）。最后，T-CRC的人类研究现在将受益于Z2项目中表型和基因典型特征良好的队列。招募正常个体和在环境或基因上容易改变饮食行为的个体，显然对下一个资助期的实验范例和有针对性的干预至关重要。

The incidence and prevalence of obesity continues to rise and is particularly observed in populations that are exposed to an unprecedented abundance of food. Against this background, it represents an urgent task to unravel the central nervous mechanisms that act to integrate the homeostatic and reward-associated neurocircuits encoding the behavioural portfolio relevant for food choice and intake. Based on the significant and exciting progress made in the first funding period, we will now expand our conceptual approach and efforts to systematically move towards a more system-based and translational research programme. To this end, we will position our goal to decipher the interaction between homeostatic and reward circuits in a broader context with regards to neuronal and functional interactions (level A). The analysis of this crosstalk will also include relevant models of social interaction and cue triggered/external eating behaviour in a more clinically oriented translational context (level B). Clearly defined intervention strategies to enable tackling these problems through neuromodulation, pharmacological means or targeted neurosurgical approaches will be employed (level C). Finally, human studies within the T-CRC will now benefit from a pheno- and genotypically well-characterized cohort in the Z2 project. The recruitment of normal individuals and individuals which are environmentally or genetically prone to altered eating behaviour is clearly essential for the experimental paradigms and targeted interventions of the next funding period.