A molecular timer for inflammation and cell death

这个项目旨在提高我们对免疫系统适时功能的理解。大多数生命的基本过程都依赖于细胞功能的及时执行。在一个生物系统中，时间是最重要的，那就是免疫系统。机体健康依赖于这一前线防御系统来快速检测入侵微生物，并诱导适当、及时的抗微生物反应来清除感染。我们目前还不了解免疫反应是如何暂时协调的。该提案旨在通过描述一种新的分子计时器来解决这一关键的知识差距，该计时器指示免疫反应和免疫细胞死亡的协调时间。这些研究可能对哺乳动物的抗微生物机制产生根本性的见解。

This project aims to improve our understanding of the timely function of the immune system. Most processes fundamental to life rely on the timely execution of cellular functions. One biological system in which timing is paramount is the immune system. Organismal health relies upon this front-line defence system for rapidly detecting invading microbes and inducing an appropriate, and timely, antimicrobial response to clear infection. We do not currently understand how immune responses are temporally coordinated. This proposal aims to address this key knowledge gap by characterising a novel molecular timer that dictates the co-ordinated timing of immune responses and immune cell death. These studies may yield fundamental insight into mammalian anti-microbial mechanisms.