MRI: Acquisition of a 400 MHz NMR Spectrometer for Use in Research and Research Training

在主要研究仪器计划(MRI)的这一奖项和化学研究仪器计划(CRIF)的支持下，苏必利尔湖州立大学的Adam Mosey教授及其同事R.Matt Werner、Steven Johnson和Martha Hutchens获得了一台400 MHz核磁共振光谱仪。这种光谱仪允许在各种领域进行研究，例如那些加速具有重大经济意义的化学反应的领域，以及对生物相关物种的研究。总的来说，核磁共振波谱是化学家用来研究分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。这些核磁共振研究的结果对合成有机/无机化学、材料化学、法医学和生物化学产生了影响。该仪器是本科生通过独立的学生研究和传统学术课程以及来自Bay Mills部落社区学院的研究人员和学生通过独立的学生研究和传统学术课程进行的教学和研究的组成部分。该奖项旨在加强各级的研究和教育，特别是在以下领域：(A)表征不对称咪唑啉环化反应的产物和机理；(B)表征基于Evans的手性辅助烯醇酸酯及其生成的Aldol反应产物；(C)研究3，4-二氢喹唑啉的抗菌活性；(D)探索化合物的法医化学，以及(E)制备同位素标记的合成大麻碱。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Adam Mosey from Lake Superior State University and colleagues R. Marshall Werner, Steven Johnson and Martha Hutchens have acquired a 400 MHz NMR spectrometer. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as the study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the study of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. The results from these NMR studies have an impact in synthetic organic/inorganic chemistry, materials chemistry, forensics and biochemistry. This instrument is an integral part of teaching as well as research performed by undergraduate students via independent student research and traditional academic coursework as well as researchers and students from the Bay Mills Tribal Community College that has a large Native American enrollment.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) characterizing the products and mechanism of an enantioselective imadazoline annulation reaction; (b) characterizing Evans-based chiral auxiliary enolates and their resulting aldol reaction products; (c) investigating the anti-microbial properties of 3,4-dihydroquinazolines and (d) exploring the forensic chemistry of compounds, and (e) preparing isotopically-labeled synthetic cannabinoids.