SuSChEM: GOALI: Enabling Photoredox Catalysis in the Industrial Setting

化学部的化学合成项目支持Gary Molander教授的项目。莫兰德教授是宾夕法尼亚大学化学系的一名教员。他发明了一种制造碳碳键的新方法。这项研究具有广泛的科学影响，因为碳-碳键用于制药、农化、精细化工、材料和商品化工（如显示设备、化妆品等）行业生产的化学品。莫兰德团队正在利用这种制造碳-碳键的新方法，朝着构建复杂分子的更可持续的方法努力。这种方法的核心在于反应是由可见光驱动的，不需要加热化学反应。这些反应也可以在没有贵重金属的情况下进行。简单的反应条件使该方法不仅更具可持续性，而且更具经济可行性。这种潜力吸引了化学公司诺华作为合作伙伴。诺华公司和Molander集团正在共同开发新反应方法的工业应用。该项目处于有机化学和无机化学的交叉点。通过该项目提供的对工业研究的深入了解，学生可以获得对工业就业市场的重要看法。项目涉及学术和工业伙伴的外联活动针对的是代表性不足的群体。光氧化还原/镍双催化为以新的方式形成新的碳-碳键提供了一种手段。这种模式与碳氢（C-H）功能化相结合，为复杂有机分子的可持续合成提供了强大的组合。在本研究中，主要进行了以下几个方面的研究：1。能否找到通过可见光催化产生酰基和烷基自由基并进行镍催化交叉偶联反应的条件？2. 分子内氢原子转移是否可以控制在烷基链上特定位置的芳基化？3. 在反应混合物中加入胺硼烷或nhc硼烷是否可以通过极性反转来改变特异性？4. 这些新的合成方法能否与诺华的合作伙伴一起应用光流技术进行大规模合成？这最后一个方面提供了扩展的可能性，并将基础科学转化为工业环境。

The Chemical Synthesis Program of the Chemistry Division supports the project by Professor Gary Molander. Professor Molander is a faculty member in the Department of Chemistry at the University of Pennsylvania. He has developed a new way of making carbon-carbon bonds. The research is of broad scientific impact since carbon-carbon bonds are used in chemicals produced by the pharmaceutical, agrochemical, fine chemical, materials, and commodity chemical (e.g., display devices, cosmetics, etc.) industries. Using this new method for making carbon-carbon bonds, the Molander group is working toward more sustainable approaches to the construction of complex molecules. Central to this method is the fact that the reactions are driven by visible light, require no heating of the chemical reaction. The reactions can also be conducted in the absence expensive, precious metals. The simple reaction conditions make the method not only more sustainable, but also more economically viable. This potential has attracted the chemical company, Novartis as a partner. Working together, Novartis and the Molander group are developing industrial applications of the new reaction methods. The project lies at the interface of organic and inorganic chemistry. With insight into industrial research provided by the project, students gain for important perspectives on the industrial job market. Outreach activities involving both academic and industrial partners in the project are targeting underrepresented groups. Photoredox/nickel dual catalysis provides a means to form new carbon-carbon bonds in new ways. This paradigm, combined with carbon-hydrogen (C-H) functionalization, provides a powerful combination for the sustainable synthesis of complex organic molecules. In the research, the following lines of inquiry are pursued: 1. Can conditions be found wherein acyl and alkyl radicals can be generated through visible light photocatalysis and engaged in nickel-catalyzed cross-coupling reactions? 2. Can intramolecular hydrogen atom transfer be controlled in a manner that allows arylation at specific sites along an alkyl chain? 3. Can the specificity be changed through polarity reversal by adding amine-boranes or NHC-boranes to the reaction mixture? 4. Can these new synthetic methods be translated to large scale synthesis using photoflow techniques with partners at Novartis? This last aspect provides outreach possibilities and translation of basic science to the industrial setting.