Collaborative: A mobile smart glucose monitoring system

本研究的目的是开发一种新型的移动的智能葡萄糖监测系统（mSGMS），该系统能够在不使用外部电源或电池的情况下检测组织液中的葡萄糖水平。在临床背景下，这项工作将提供一种新的连续葡萄糖测量技术，该技术在检测葡萄糖水平的瞬时变化方面更加有效。mSGMS将提供更快的分析和更好的诊断信息，并具有快速响应血糖水平异常的额外好处。连续监测血糖的能力意味着不再需要频繁采集血液，从而带来一定程度的不便和痛苦。 与数据传输-通信模块集成的智能葡萄糖监测系统有可能取代在医疗保健应用中用于监测血糖的连续葡萄糖监测仪（CGM）。将开展教育推广活动和研究经验，使巴尔的摩地区的高中生、本科生和研究生参与拟议的研究。这项工作将在改善血糖控制和改善生活质量方面具有重要意义，并发症更少，医疗费用更低。提出了一类新型的可伸展的和灵活的移动的智能葡萄糖监测系统（mSGMS），其能够进行连续葡萄糖测量，在检测来自组织液的葡萄糖水平的瞬时变化方面更加有效。mSGMS的开发将通过以下具体目标来实现：（目标1）设计、制造和测试能够检测葡萄糖水平的智能葡萄糖监测系统。(Aim 2）开发一种移动的智能血糖监测系统（mSGMS），其集成无线遥测并执行数据收集、信号处理、数据分析以及向患者和护理人员的信息传输，并且（目的3）封装智能血糖监测系统。所提出的研究是创新性的，因为mSGMS通过电荷泵集成电路（IC）产生并在电容器中积累电力，作为用于感测葡萄糖的间质葡萄糖的氧化的结果，而不使用恒电位器电路或外部电源，同时通过DC-DC转换器为数据采集、处理和数据传输-通信模块供电。这项研究提供了巨大的机会，以克服商业上可用的葡萄糖监测技术的局限性，通过提供一种设备，允许灵敏和快速检测间质葡萄糖浓度的瞬时变化。这项研究将在1型糖尿病患者的组织液样本中产生持续的葡萄糖记录，该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The objective of this research proposal is to develop a class of novel mobile smart glucose monitoring system (mSGMS) that is able to detect glucose levels from interstitial fluid without the use of an external power source or a battery. In a clinical context, the work will provide a new technique for continuous glucose measurement that is far more effective at detecting transient changes in glucose levels. The mSGMS will provide faster analysis and better diagnostic information, with the added benefit of responding rapidly to abnormalities in glucose levels. The ability to continuously monitor glucose means it will no longer be necessary to frequently sample blood with some associated degree of inconvenience and pain. The smart glucose monitoring system integrated with data transmission-communication modules could potentially replace continuous glucose monitors (CGMs) used in monitoring blood glucose in healthcare applications. Educational outreach activities and research experiences will be developed to engage Baltimore area high school students, undergraduates, and graduate students in the proposed research. This work will be of significant use in improving glycemic control and improving the quality of life with fewer complications and lower healthcare costs. A class of novel stretchable and flexible mobile smart glucose monitoring system (mSGMS) capable of continuous glucose measurement that is far more effective at detecting transient changes in glucose levels from interstitial fluid is proposed. The development of the mSGMS will be achieved through the following specific aims: (Aim 1) Design, fabricate and test the smart glucose monitoring system capable of detecting glucose levels. (Aim 2) Develop a mobile smart glucose monitoring system (mSGMS) that integrates wireless telemetry and performs data collection, signal processing, data analysis, and information transmission to patient and caregivers, and (Aim 3) encapsulate the smart glucose monitoring system. The proposed research is innovative because the mSGMS generates and accumulates electrical power in a capacitor via a charge pump integrated circuit (IC) as a result of the oxidation of interstitial glucose for sensing glucose without the use of a potentiostat circuit or an external power source, while simultaneously via a DC-DC converter powering the data acquisition, processing, and data transmission-communication modules. This research offers tremendous opportunities to overcome the limitations of commercially available glucose monitoring technologies by providing a device that allows sensitive and rapid detection of transient changes in interstitial glucose concentration. The proposed studies will generate continuous glucose recording in interstitial fluid samples from patients with type 1 diabetes for long duration.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.