MRI: Acquisition of a 400 MHz NMR Spectrometer at Fairfield University

该奖项由主要研究仪器和化学研究仪器计划支持。费尔菲尔德大学的John Miecznikowski教授和同事Matthew Kubasik、Aaron货车Dyke和Jillian Smith-Carpenter获得了一台配备自动采样器的400 MHz NMR光谱仪。该光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应，以及研究生物相关物种。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。该仪器对该机构和附近的艾奥纳学院的学生产生了积极影响。该研究小组正在与费尔菲尔德大学的向上拓展计划合作，为来自布里奇波特、CT学校系统和大多数学生的9- 12年级学生举办一系列为期一天的科学仪器讲习班。这些学生中的许多人认为自己是少数民族和低收入者。他们还与费尔菲尔德大学的年度扩大科学教育（BASE）营地合作，该营地面向来自布里奇波特学校的当地高中生，他们与教师导师一起参与实践研究经验。该提案旨在加强各级的研究和教育。它特别有助于开发基于锌（II）钳配合物的水溶性羰基还原预催化剂和螺旋肽构象动力学的研究。该光谱仪在表征捕获-标签-释放探针的合成产物以标记内源性酶（如组蛋白脱乙酰酶）以及通过1，2-二硫戊环官能化自组装肽的合成制备的合成产物方面至关重要。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估来支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor John Miecznikowski from Fairfield University and colleagues Matthew Kubasik, Aaron Van Dyke and Jillian Smith-Carpenter have acquired a 400 MHz NMR spectrometer equipped with an automatic sampler. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The instrument positively impacts students at this institution and at nearby Iona College. The research team is partnering with the Upward Bound Program at Fairfield University by hosting a series of one-day scientific instrumentation workshops for 9-12th graders from the Bridgeport, CT school system and most of the students. Many of these students identify themselves as minority and low-income. They also partner with the annual Broadening Access to Science Education (BASE) Camp at Fairfield University directed to local high school students from Bridgeport schools who participate in hands-on research experiences with faculty mentors. The proposal is aimed at enhancing research and education at all levels. It especially aids the development of water-soluble carbonyl reduction precatalysts based on zinc(II) pincer complexes and studies of helical peptide conformational dynamics. The spectrometer is essential in characterizing synthetic products of capture-tag-release probes to label endogenous enzymes, such as histone deacetylases, and those prepared thorough synthesis of 1,2-dithiolane functionalized self-assembling peptides.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.