MRI: Upgrade of a 400 MHz NMR Spectrometer to Support Research, Research Training, and Chemical Education

该奖项由主要研究仪器项目和化学研究仪器项目支持。索尔兹伯里大学的Jose Juncosa教授和他的同事Seth Friese升级了一台400 MHz核磁共振光谱仪的控制台，并为由此产生的光谱仪配备了一个自动转换器，允许学生收集多个样本的数据。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。该工具对与人合著论文并在地方和国家会议上展示其结果的学生研究人员产生了积极影响。光谱仪在其推广活动中促进了更多的研究机会，并为科学和工程领域的后代提供了能力。核磁共振光谱仪对更广泛地理区域的研究和研究培训活动的质量和生产率有直接影响，特别是在德尔马瓦半岛的下东岸。该光谱仪与马里兰东岸大学的研究人员共享，这是一所邻近的历史悠久的黑人学院和大学(HBCU)。该提案旨在加强各级研究和教育。它尤其有助于5-羟色胺受体5-羟色胺受体的合成激动剂的表征和新的含氮供体配体的设计。该光谱仪用于表征通过恶唑盐转化合成的生物碱，并用于鉴定基因和酶。该仪器帮助研究人员开发可切换的磁共振成像造影剂，与MRI扫描设备一起使用，并用于分析合成的2-氧代吡咯烷酮杂化类似物。核磁共振波谱仪还被用于寻找生物活性微生物天然产物和混合抗氧化剂/毒扁豆碱激动剂，它们是激活某些神经元和其他细胞细胞膜上的M胆碱受体活性的试剂。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor Jose Juncosa from Salisbury University and colleague Seth Friese have upgraded the console of a 400 MHz NMR spectrometer and equipped the resulting spectrometer with an automatic changer that allows students to collect data on multiple samples. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The instrument positively impacts student researchers who coauthor papers and present their results at local and national conferences. The spectrometer promotes enhanced research opportunities in its outreach, and empowers future generations in science and engineering. The NMR spectrometer has a direct impact on the quality and productivity of research and research training activities in the broader geographic region, particularly the lower Eastern Shore of the Delmarva Peninsula. The spectrometer is shared with researchers at the University of Maryland Eastern Shore, a neighboring Historically Black College and University (HBCU).The proposal is aimed at enhancing research and education at all levels. It especially aids in the characterization of synthetic agonists for the serotonin receptor denominated 5-HT-24 and the design of new nitrogen-containing donor ligands. The spectrometer is used to characterize alkaloids synthesized using oxazolium salt transformations and to identify genes and enzymes. The instrument helps researchers developing switchable magnetic resonance imaging contrast agents used in conjunction with MRI scanning devices and for the analysis of synthetic 2-oxopyrroline enaminone hybrid analogues. The NMR spectrometer is also utilized on the search for bioactive microbial natural products and for hybrid antioxidants/muscarinic agonists which are agents that activates the activity of the muscarinic acetylcholine receptor in cell membranes of certain neurons and other cells.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.