Conference: FASEB Summer Research Conference on Dynamic DNA Structures in Biology, July 2018, St. Bonaventure University, Olean, NY

该奖项将支持研究生和博士后研究人员参加将于2018年7月8日至13日在纽约州奥林市圣博纳文图尔大学举行的FASEB生物学动态DNA结构会议。这是一个不断发展的领域，将在核酸化学、生物化学、遗传学和基因组结构和功能方面具有互补兴趣的研究人员聚集在一起。会议将包括该领域两位领导人的主题演讲。正式会议将包括全体讲座、会谈和海报会议，以鼓励分享最新的研究成果。将为初级研究人员提供非正式的机会，在“与演讲者见面”的午餐会上向知名研究人员学习，并与来自学术界和工业界的高级研究人员进行职业讨论。DNA分子是高度动态的，可以采用多种构象，在基因和基因组的功能和调控中发挥重要作用。本次会议将重点介绍该领域的最新进展，包括基因编辑以及染色质和DNA损伤反应在转录相关基因组不稳定性中所起的作用。其他讨论的主题是染色体断裂和基因组重排；结构诱导的基因组不稳定性；通过路障进行复制；transcription-induced突变;可扩展DNA重复序列与人类疾病；DNA修复和重排，以及g -四重体。会议将为初级研究人员提供一个极好的论坛，包括那些来自代表性不足的群体的研究人员，听取美国和国外的最新研究，与该领域的领导者会面和交谈，并有机会展示和接受他们自己的研究反馈。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award will support attendance by graduate students and postdoctoral researchers at the FASEB Conference on Dynamic DNA Structures in Biology to be held July 8-13, 2018 at St. Bonaventure University, Olean, NY. This is an evolving field that continues to bring together researchers with complementary interests in nucleic acid chemistry, biochemistry, genetics, and genome architecture and function. The meeting will include keynote lectures by two leaders in the field. Formal sessions will include a combination of plenary lectures, talks and poster sessions to encourage sharing of latest research results. Informal opportunities will be provided for junior researchers to learn from established investigators at a 'meet the speakers' lunch and a career discussion with senior researchers from both academia and industry. DNA molecules are highly dynamic and can adopt a variety of conformations that play important roles in the function and regulation of genes and genomes. Recent advances in the field--including gene editing and the role played by chromatin and the DNA damage response in transcription-associated genome instability--will be highlighted in this meeting. Other topics for discussion will be chromosome breaks and genomic rearrangements; structure-induced genome instability; replication through roadblocks; transcription-induced mutations; expandable DNA repeats and human disease; DNA repair and rearrangement, and G-quadruplexes. The meeting will bring provide an excellent forum for junior investigators, including those from underrepresented groups, to hear about latest research in the U.S. and abroad, to meet and talk with leaders in the field, and to have an opportunity to present and receive feedback on their own research.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.