Meeting: Stress phenotype: linking molecular, cellular and physiological stress (Society of Integrative and Comparative Biology Symposium, January 5, 2019 in Tampa, FL).

大多数生物体通过应激反应来应对环境和社会压力。然而，从分子到细胞，再到整个生物体，关于应激反应是如何跨组织水平整合的知识仍然有限。本次研讨会将汇集不同层次的组织和不同职业阶段的生物学家，以获得对生物体如何应对压力的更丰富的见解。研讨会期间，来自不同级别组织的发言人将轮流发言。紧接在研讨会之后，将举办一个结构化的圆桌讨论，旨在确定压力生物学中的关键突出问题，以及可用于研究动物（包括家养和稀有物种）跨组织水平的压力反应的综合方法。还将为来自不同背景的早期职业科学家提供免费的口头和海报会议，以增加处于不同职业阶段的科学家之间的思想交流和合作的潜力，这些科学家传统上在不同的分析水平上研究压力反应。大多数生物体在面对环境和社会压力时，会产生高度保守的应激反应。然而，关于应激反应如何在从基因组到现象的生物组织水平上整合的信息是不完整的。然而，越来越清楚的是，全面了解应激反应的演变将需要跨分析水平的综合研究。这些信息对于预测选择将如何影响这种复杂表型在有机体水平上的表达，以及潜在机制的整合将如何影响对选择的进化反应至关重要。由于各种生物在面对人为干扰和快速变化的环境时预计会经历越来越多的压力暴露，这方面的知识变得越来越紧迫。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

Most organisms respond to environmental and social stressors by a stress response. However, knowledge of how the stress response is integrated across levels of organization from molecules, to cells, to the whole organism remains limited. This symposium will bring together biologists across levels of organization and at different career stages to gain a richer insight into how organisms respond to stress. During the symposium, speakers from different levels of organization will alternate with one another. Immediately following the symposium, a structured round table discussion will be hosted aimed at identifying key outstanding questions in stress biology and integrative approaches that can be used to study the stress responses of animals, including domesticated and rare species, across levels of organization. There will also be complimentary oral and poster sessions geared towards early career scientists from diverse backgrounds to increase the potential for idea exchange and collaborations between scientists at different career stages and that traditionally study the stress response at different levels of analyses.Most organisms initiate a highly conserved stress response in the face of environmental and social stressors. Yet, information about how the stress response is integrated across levels of biological organization from genomes to phenomes is incomplete. However, it is becoming increasingly clear that a comprehensive understanding of the evolution of the stress response will require integrative studies that span levels of analyses. This information will be critical for predicting how selection will influence the expression of this complex phenotype at the organismal level, as well as how the integration of the underlying mechanisms will influence the evolutionary response to selection. As diverse organisms are expected to experience rising stress exposure in the face of anthropogenic disturbance and rapidly changing environments, this knowledge is becoming increasingly urgent.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.