SPP 1710: Dynamics of Thiol-Based Redox Switches in Cellular Physiology

近年来，人们发现，活性氧和氮物质尽管传统上被认为是自由基链的组成部分和损伤的预兆，但它们在信号传导中却充当着生理上重要的信使。特定氧化剂的信号传导性质主要由“蛋白质硫醇开关”感测和介导，所述蛋白质硫醇开关是通过氧化特异性且可逆地修饰的蛋白质硫醇，从而在不同构象和功能状态之间切换蛋白质。尽管硫醇开关具有基本的细胞生物学和医学重要性，但我们才刚刚开始了解它们的特异性原理、它们的作用机制以及它们在信号转导的时空操作中的作用。

In recent years it has become evident that reactive oxygen and nitrogen species, despite their traditional reputation as components of radical chains and harbingers of damage, act as physiologically essential messengers in signal transduction. The signalling properties of particular oxidants are primarily sensed and mediated by "protein thiol switches", which are protein thiols that are specifically and reversibly modified by oxidation, thereby switching the protein between different conformational and functional states. In spite of the fundamental cell biological and medical importance of thiol switches we are only beginning to understand their principles of specificity, their mechanism of action and their role in the spatio-temporal operation of signal transduction.