Enantioenriched Silanol and Siloxy Compounds as Catalysts and Ligands

有了这个奖项，NSF化学部的化学催化计划正在支持加州大学戴维斯分校化学系Annaliese Franz教授的研究。Franz教授正在开发新的硅基分子，并利用它们来制备结构确定的金属络合物。这些配合物正在研究作为催化剂的应用，如有机材料和可再生聚合物的有效合成，用于技术，医学和日常生活。催化剂的使用对于提高先进制造业的工业效率和减少废物产生非常重要。 硅是地壳中第二丰富的元素，因此这项研究正在解决可持续性问题。 该项目也有助于培养下一代科学家和扩大参与。弗兰兹从事指导和推广活动，以扩大在干的参与，包括示范和讲习班为7日和8日年级的女孩与AAUW TechTrek和干女孩。她还设计并实施了一年级研讨会-CURE（基于课程的本科生研究体验）-让不同的一年级学生和转学生参与实践研究机会，培养关键技能，帮助他们进入科学和技术领域。该项目旨在开发具有高催化活性和选择性的新型金属硅氧化物复合物，用于手性分子的合成。本文设计合成了四类新的手性硅氧基化合物，用于制备手性配体。使用这些新设计的硅烷醇配体，一系列新的金属-硅氧化物配合物正在制备中的金属配位能力，结构研究，稳定性和催化活性进行了检查。新催化剂的结构、结合相互作用和机理正在使用各种光谱学方法、动力学、X射线晶体学和质谱法进行研究。该项目还培训本科生和研究生发展化学合成和催化的技术和批判性思维技能。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响力进行评估而被认为值得支持审查标准。

With this award, the Chemical Catalysis Program of the NSF Division of Chemistry is supporting the research of Professor Annaliese Franz in the Department of Chemistry at the University of California, Davis. Professor Franz is developing new silicon-based molecules and using them to prepare structurally-defined complexes with metals. These complexes are being studied as catalysts for applications such as the efficient synthesis of organic materials and renewable polymers that are used in technology, medicine, and daily life. The use of catalysts is important for increasing industrial efficiency in advanced manufacturing and reducing waste production. Silicon is the second most abundant element in the earth's crust, as such this research is addressing issues of sustainability. This project alsocontributes to training the next generation of scientists and broadening participation. Dr. Franz engages in mentoring and outreach activities to broaden participation in STEM, including demonstrations and workshops for 7th and 8th grade girls with AAUW TechTrek and STEM for Girls. She also designs and implements a First-year Seminar - CURE (Course-based Undergraduate Research Experience) - to engage a diverse group of first-year and transfer students with hands-on research opportunities to build critical skills that will help launch them into careers in science and technology.This project aims to develop new metal-siloxide complexes with high catalytic activity and selectivity for the synthesis of chiral molecules. The design and synthesis of four new classes of chiral siloxy compounds is being investigated to prepare chiral ligands. Using these newly designed silanol ligands, a series of novel metal-siloxide complexes is being prepared where the metal-coordinating abilities, structural studies, stability, and catalytic activity are examined. The structure, binding interactions, and mechanism of the new catalysts are being studied using various spectroscopy methods, kinetics, X-ray crystallography, and mass spectrometry. This project is also training undergraduate and graduate students to develop technical and critical thinking skills for chemical synthesis and catalysis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.