MRI: Acquisition of a Hybrid Quadrupole Mass Spectrometer with an Ultra-High Pressure Chromatograph

该奖项由重大研究仪器和化学仪器项目支持。爱荷华大学的伊丽莎白·斯通教授及其同事詹姆斯·格洛尔、克里·霍恩巴克和大卫·克维尔特尼正在获取一种具有电喷雾电离(ESI)能力并配备超高压色谱仪(UPLC)的混合式四极轨道质谱仪。通常，质谱仪是用于鉴定和表征复杂样品中少量化学物种的关键分析方法之一。在一个典型的实验中，这些成分流入质谱仪，在那里它们被电离，并测量离子的质量。带有液体色谱仪的仪器可以在混合物到达质谱计之前将其分离。此次收购加强了该大学和该地区的研究基础设施。该仪器通过让不同的学生群体参与研究和使用这种现代分析技术进行研究培训，扩大了参与度。使用该仪器的一些项目包括爱荷华州斯隆模范导师中心、夏季研究机会计划、爱荷华州生物科学学院和NSF支持的可持续水资源发展计划。在环境化学、水处理、生物修复、天然产物、药物化学和食品安全领域的科学知识的进步有助于取得具有社会意义的成果。获奖者奖加强了各级的研究和教育。它尤其影响分子大气气溶胶的特性，并改善饮用水质量。质谱仪还用于确定环境中类固醇和其他药物以及真菌生物活性产品的结果。该仪器还为研究人员评估多氯联苯的毒性和修复以及那些表征环境污染物的方法提供服务。此外，质谱仪有助于发现新出现的水污染物的转化产物和途径，并调查活跃环境界面的表面膜。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemical Instrumentation Programs. Professor Elizabeth Stone from the University of Iowa and colleagues James Gloer, Keri Hornbuckle and David Cwiertny are acquiring a hybrid quadrupole-Orbitrap mass spectrometer with electrospray ionization (ESI) capabilities and equipped with an ultra high pressure chromatograph (UPLC). In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species in complex samples. In a typical experiment, the components flow into a mass spectrometer where they are ionized and the ions' masses are measured. An instrument with a liquid chromatograph can separate mixtures of compounds before they reach the mass spectrometer. The acquisition strengthens the research infrastructure at the University and regional area. The instrument broadens participation by involving diverse groups of students in research and research training using this modern analytical technique. Some of the programs using the instrument are the Iowa Sloan Center for Exemplary Mentoring, Summer Research Opportunities Program, the Iowa Biosciences Academy, and an NSF-supported Sustainable Water Development Program. Advancement of scientific knowledge in the areas of environmental chemistry, water treatment, bioremediation, natural products, medicinal chemistry, and food safety contribute to the achievement of societally-relevant outcomes.The acquisition award enhances research and education at all levels. It especially impacts the characterization of molecular atmospheric aerosols and improves drinking water quality. The mass spectrometer is also used to identify the outcomes of steroids and other pharmaceuticals in the environment and bioactive products from fungi. The instrument also serves researchers evaluating toxicity and remediation of polychlorinated biphenyls as well as those characterizing environmental contaminants. In addition, the mass spectrometer aids in the discovery of transformation products and pathways of emerging water contaminants, and investigations of surface films at active environmental interfaces.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.