MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer for a Cluster of Primarily Undergraduate Institutions in Rhode Island

该奖项由化学仪器（CRIF）计划，刺激竞争性研究的既定计划（EPSCoR）和主要研究仪器（MRI）计划共同资助。来自普罗维登斯学院的Seann Mulcahy教授及其同事Christopher Laperle、Christopher Reid（布莱恩特大学）、Maria卡罗尔和Chin Hin Leung（罗得岛学院）正在购买一台400 MHz核磁共振（NMR）光谱仪，以取代旧的光谱仪。一般来说，NMR光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。化学家的一个典型用途是分析反应的混合物以确定产物。该仪器是教学的一个组成部分，以及由本科生在普罗维登斯学院和邻近的罗得岛学院和布莱恩特学院进行的研究。它也用于讲座和实验室课程，为学生的职业生涯做准备。该奖项旨在加强各级的研究和教育。正在研究各种研究项目。其中一个项目涉及研究含氮杂环的有机合成和β-咔啉阻转异构体（由于围绕单键旋转受阻而产生的立体异构体）的立体对称制备，以用于化学催化和药物化学应用。研究了电催化还原二氧化碳的可能补救的化合物。另一个项目是研究溶剂化对原型五羰基铁催化的光辅助反应的影响，以改善有机合成中的这一过程。正在研究用于可能的医药用途和环境应用的可官能化和可降解的聚合物。正在合成细菌N-乙酰氨基葡萄糖苷酶的小分子抑制剂，以促进对细胞壁代谢的理解。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly funded by the Chemical Instrumentation (CRIF) program, the Established Program to Stimulate Competitive Research (EPSCoR), and the Major Research Instrumentation (MRI) program. Professor Seann Mulcahy from Providence College and colleagues Christopher Laperle, Christopher Reid (Bryant University), Maria Carroll and Chin Hin Leung (Rhode Island College) are acquiring a 400 MHz nuclear magnetic resonance (NMR) spectrometer to replace an older one. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. A typical use by a chemist is to analyze the mixture from a reaction to determine the products. This instrument is an integral element of teaching as well as research performed by undergraduate students at Providence College and neighboring Rhode Island College and Bryant College. It is also used in lecture and laboratory courses to prepare students for their careers. The award is aimed at enhancing research and education at all levels. A variety of research projects are being investigated. One project involves studying the organic synthesis of nitrogen-containing heterocycles and the stereosymmetric preparation of beta-carboline atropisomers (stereoisomers arising because of hindered rotation about a single bond) for chemical catalysis and medicinal chemistry applications. Electrocatalytic reduction of carbon dioxide is studied for possible remediation of the compounds. Another project is investigating solvation effects on prototypical iron pentacarbonyl-catalyzed photoassisted reactions to improve this procedure in organic synthesis. Functionalizable and degradable polymers for possible medicinal use and environmental applications are being investigated. Small molecule inhibitors of bacterial N-acetylglucosaminidases are being synthesized to foster understanding of cell wall metabolism.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.