MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer to Support Undergraduate Research at High Point University

该奖项由主要研究仪器和化学仪器项目支持。高点大学的帕梅拉·伦丁教授和他的同事安德鲁·沃马克、梅丽莎·斯鲁吉和梅根·布莱克利奇正在获取一台400 MHz的核磁共振光谱仪，该光谱仪将取代老式的低场光谱仪。总的来说，核磁共振波谱是化学家可以用来确定分子结构的最强大的工具之一。核磁共振波谱被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。核磁共振研究提高了对合成有机/无机化学、材料化学和生物化学的理解。该仪器是教学和研究的一个组成部分，由本科生和研究生以及在这个不断发展的机构的几名早期职业教师进行。在使用该仪器的同时，学生们获得了基本的分析技能，使他们成为工业职业和研究生课程更具竞争力的候选人。此外，核磁共振光谱仪被纳入该机构的移动社区实验室使用的不断发展的仪器组合中。核磁共振被用来向当地的初中生和高中生解释结构化学和动力学的概念，并扩大对STEM(科学、技术、工程和数学)计划的参与。核磁共振光谱仪的获奖旨在加强各级的研究和教育。它特别影响聚合产物的表征，如聚(3-己基噻吩基)和聚苯乙炔的聚合产物的表征，以及利用硫醇-烯偶联反应生成氧化还原惰性二硫化物生物同工质。该仪器还服务于研究人员阐明抗抑郁药二苯并西平抑制蛋白丝氨酸/苏氨酸(Stk1)激酶的机制，以及那些设计、合成和表征苯醌结构的人。这些研究项目有益于国家健康和福利以及教育和多样性努力。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Instrumentation Programs. Professor Pamela Lundin from High Point University and colleagues Andrew Wommack, Melissa Srougi and Meghan Blackledge are acquiring a 400 MHz Nuclear Magnetic Resonance (NMR) spectrometer that replaced an older low-field spectrometer. In general, NMR spectroscopy is one of the most powerful tools available to chemists to determine of the structure of molecules. NMR spectroscopy is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The NMR studies improve understanding of synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument is an integral part of teaching as well as research performed by undergraduate and graduate students and several early career faculty members at this growing institution. While using the instrument, students gain essential analytical skills that allow them to become more competitive candidates for industrial careers and graduate school programs. In addition, the NMR spectrometer is incorporated into the evolving portfolio of instrumentation utilized by this institution's Mobile Community Laboratory. NMR is used to illustrate the concepts of structural chemistry and kinetics to local middle and high school students and to expand participation in STEM (science, technology, engineering and mathematics) programs.The award of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts the characterization of polymerization products such as those of poly(3-hexylthiophene) and poly(phenylene ethynylenes) and the use of thiol-ene coupling reactions to generate redox-inert disulfide bioisosteres. The instrumentation also serves researchers elucidating the mechanism of antidepresant-dibenzazepine inhibition of protein serine/threonine (Stk1) kinase, and those designing, synthesizing and characterizing quinone structures. These research projects benefit the National health and welfare as well as education and diversity efforts.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.