MRI: Acquisition of High-Resolution Mass Spectrometer for Research in Materials and Biological Chemistry

该奖项由重大研究仪器和化学仪器项目支持。新墨西哥大学的Jeffrey Rack教授及其同事Martin Kirk和杨芹正在获得一台超高压四极飞行时间质谱仪(UPLC-QTof-MS)。通常，质谱仪是用于识别和表征复杂样品中的少量化学物种的关键分析方法之一。在一个典型的实验中，这些成分流入质谱仪，在那里它们被电离成离子，并测量离子的质量。这种高度灵敏的技术使研究复杂混合物中的分子结构成为可能。带有液体色谱仪的仪器可以在混合物到达质谱计之前将其分离。利用飞行时间质谱仪的方法，通过离子被已知强度的电场加速的时间测量的方法来确定离子的质荷比。这种加速使一个离子具有与具有相同电荷的任何其他离子相同的动能。此次收购加强了该大学和该地区的研究基础设施。该仪器通过利用这一现代分析技术让不同的学生群体参与研究和研究培训，扩大了参与范围，并支持许多用户和代表性不足的学生。它还为本科生提供培训机会，其中许多是第一代学生。该仪器给学生提供了使用重要仪器的经验，他们将把这些仪器带到他们的职业生涯中。授予这种质谱仪的目的是为了加强各级的研究和教育。它特别适用于开发具有光活性的化合物和材料，以及设计分子电子学的载体磁性材料。该仪器还用于评估柔性光电子应用的聚硫杂乙烯共轭聚合物，以及用于筛选生物活性物种文库的开发平台。质谱仪还用于表征可能与肝和脾疾病相关的Niemann-Pick C1代谢途径相关的通用结构，破译一氧化氮合酶的构象控制以及标记具有稳定同位素的潜在药物。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemical Instrumentation Programs. Professor Jeffrey Rack from the University of New Mexico and colleagues Martin Kirk and Yang Qin are acquiring an ultra high-pressure, quadrupole, time-of-flight mass spectrometer (UPLC-QTof-MS). In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex samples. In a typical experiment, the components flow into a mass spectrometer where they are ionized into ions and the ions' masses are measured. This highly sensitive technique allows the structure of molecules in complex mixtures to be studied. An instrument with a liquid chromatograph can separate mixtures of compounds before they reach the mass spectrometer. Using the time-of-flight method of mass spectrometry, the mass-to-charge ratio of an ion is determined by the way of a time measurement in which ions are accelerated by an electric field of known strength. This acceleration results in an ion having the same kinetic energy as any other ion that has the same charge. The acquisition strengthens the research infrastructure at the University and regional area. The instrument broadens participation by involving diverse groups of students in research and research training using this modern analytical technique and supports many users and underrepresented students. It also provides training opportunities to undergraduate students, many of whom are first-generation students. The instrument gives students experience using vital instrumentation that they carry with them into their careers.The award of this mass spectrometer is aimed at enhancing research and education at all levels. It is especially useful for developing photoactive compounds and materials and for designing support magnetic materials for molecular electronics. The instrument is also employed in evaluating polychalcogenylene vinylene conjugated polymers for flexible optoelectronic applications and for developing platforms for screening libraries of bioactive species. The mass spectrometer is also utilized for the characterization of generic architectures that may be related to the Niemann-Pick C1 metabolic pathway associated with liver and spleen disorders and for deciphering the conformational control of nitric oxide synthases as well as labeling potential drugs with stable isotopesThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.