Symposium: Building Bridges from Genome to Phenome: Molecules, Methods and Models, Austin, TX; January 3-7, 2020

该奖项将支持2020年1月3日至7日在得克萨斯州奥斯汀举行的整合与比较生物学学会(SICB)年会上的一次研讨会，题为“构建从基因组到现象组的桥梁：分子、方法和模型”。口头和海报演示以及相关活动将涵盖广泛的科学努力，以了解基因如何塑造物种特有的特征，同时也会引起个体差异。理解基因导致表型稳定和变异的机制基础是美国国家科学基金会提出的重大挑战之一。许多学科的科学家正在采取各种各样的方法来剖析基因产生表型的机制基础，这被称为基因组到表型组研究。本次研讨会的目标将是在这些最成功的研究努力中建立联系，并确定关键差距和未来需要，以加速和促进这一关键领域的研究。建筑桥梁研讨会的活动旨在鼓励和支持现有和新的研究人员以及博士后、研究生和本科生研究人员的发言和参与，这些研究人员代表性别和种族的多样性，并在SICB代表的广泛学科领域具有专业知识。综上所述，研讨会的活动旨在促进在理解恒定和变异背后的过程方面取得快速和有洞察力的进展，使物种有可能在不断变化的世界中保持弹性。研讨会的报告，以及研讨会和相关活动的总结论文，将通过发表在SICB期刊上广泛传播。研讨会由NSF支持的动物基因组到基因组研究协调网络(AG2P RCN)的成员组织，该网络成立于五年前。AG2P区域协调委员会的第一次专题讨论会和政策研讨会是在2016年SICB会议上举行的。讲习班产生的白皮书强调，有必要使转录数据的分析标准化并降低障碍，以便来自多个学科和研究环境的科学家能够就将基因组与表型多样性联系起来的“起始点”制定协商一致的方法。自2016年以来，实验生物体以及描述不同水平生物组织的大型复杂数据集大量涌现，所有这些数据集都旨在阐明基因组到表型组框架的各个方面。2020年建筑桥梁研讨会旨在确定和弥合这一框架中的差距，以及基因组到表型组研究的最有前途的未来方向。除了口头和海报介绍外，研讨会还包括一个介绍性会议，以开始交流想法和联系信息；(2)一个Twitter订阅源，收集SICB成员对跨学科、组织水平和模型整合数据的主要障碍的评论；以及(3)一个政策研讨会，概述一份白皮书，确定基因组到现象组研究领域的主要差距、关键障碍和前沿。研讨会和相关活动将采用跨学科协作模式，为与会者提供有意义的专业和科学发展机会，以及跨学科、性别、族裔和专业职级相互建立网络的正式和非正式机会。研讨会的所有报告都将发表在SICB期刊上，因此将被广泛传播，并在该领域产生更广泛的影响。本次会议由NSF-生物综合组织生物学内的综合生态生理学和生理机制和生物力学项目共同资助。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award will support a symposium, "Building Bridges from Genome to Phenome: Molecules, Methods and Models," at the Annual Meeting of the Society for Integrative and Comparative Biology (SICB) meeting in Austin, Texas, Jan. 3-7, 2020. The oral and poster presentations and related activities will cover a broad range of scientific efforts to understand how genes can shape species-specific characteristics while also giving rise to individual variation. Understanding the mechanistic basis by which genes give rise to both stability and variation in phenotypes is one of the Grand Challenges articulated by NSF. Scientists in many disciplines are taking a wide variety of approaches to dissect the mechanistic bases by which genes give rise to phenotypes, called genome-to-phenome studies. The goal of this Symposium will be to build connections among the most successful of these research efforts, as well as to identify key gaps and future needs to accelerate and facilitate this critical area of research. Activities of the Building Bridges Symposium are designed to encourage and support presentations and participation by established and new investigators, as well as postdoctoral, graduate and undergraduate researchers representing diversity in gender and ethnicity, and with expertise in the wide range of disciplines represented within SICB. Taken together, the Symposium activities aim to facilitate rapid and insightful progress toward understanding the processes underlying constancy and variation, making it possible for species to be resilient in a changing world. Presentations from the Symposium, and a summary paper resulting from the Symposium and associated activities, will be widely disseminated via publication in the SICB journal.The Symposium is organized by members of the NSF-supported Animal Genome-to-Phenome Research Coordination Network (AG2P RCN), which was established five years ago. The AG2P RCN's first symposium and policy workshop were conducted at the 2016 SICB Meeting. The white paper resulting from that workshop emphasized the need to standardize and lower the barriers for analysis of transcriptomic data, so that scientists from many disciplines and research environments could develop consensus approaches for the "taking-off point" for linking genomic with phenotypic diversity. Since 2016, there has been a huge proliferation of experimental organisms as well as of large and complex datasets describing various levels of biological organization, all aiming to elucidate aspects of the genome-to-phenome framework. The 2020 Building Bridges Symposium aims to identify and bridge gaps in this framework and the most promising future directions for genome-to-phenome research. In addition to oral and poster presentations, the Symposium includes an introductory session to initiate exchange of ideas and contact information, (2) a Twitter feed to gather comments from SICB members regarding major barriers to integrating data across disciplines, levels of organization and models, and (3) a policy workshop to outline a white paper identifying major gaps, key barriers and leading edges in the field of genome-to-phenome research. The Symposium and related activities will use an interdisciplinary collaborative model that will provide meaningful professional and scientific development opportunities as well as formal and informal opportunities for participants to network with each other across disciplines, gender, ethnicity, and professional ranks. All presentations in the Symposium will be published in the SICB journal and thereby will be widely disseminated and have abroader impact on the field.This conference is being co-funded by the Integrative Ecological Physiology and Physiological Mechanisms and Biomechanics Programs within NSF-BIO-Integrative Organismal Biology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.