Electrical activity in early enteric neuron development

肠道运动和分泌物对人类和动物的健康和营养至关重要。 这些功能由肠壁内的大型神经系统（肠神经系统）调节。 该项目将确定肠神经细胞如何发育以及它们的行为如何影响其他肠神经细胞的发育。 这将为旨在开发慢性便秘和肠易激综合征等疾病的治疗方法的更多应用研究提供重要基础。 它也将有助于越来越多的知识，如何表观遗传因素可以修改神经系统内的遗传程序化发展。

Intestinal movements and secretion are critical to the good health and nutrition of both humans and animals. These functions are regulated by a large nervous system contained within the intestinal wall, the enteric nervous system. This project will identify how enteric nerve cells develop and how their behaviour influences the development of other enteric nerve cells. This is will provide an important base for more applied research aimed at developing treatments for diseases like chronic constipation and irritable bowel syndrome. It will also contribute to the growing knowledge about how epigenetic factors can modify genetically programmed development within the nervous system.