Mid-scale RI-2 Consortium: Network for Advanced NMR

核磁共振波谱是研究分子结构和动力学的重要工具。该奖项将支持在美国建立一个地理分布的先进核磁共振(NAN)网络，以提供超高场核磁共振光谱仪，使用户能够解决重要和多样化的科学问题，并教育和培训下一代科学家和工程师。由这些系统实现的科学研究领域涵盖了从分子到整个细胞和组织、复杂混合物、代谢组学和天然产物等不同生物系统的结构生物学、动力学和功能的广泛问题。非生物应用包括但不限于非晶态材料、电池组件、药物成分、纳米材料、表面涂层和催化剂。用户支持和培训将通过社区推广和一个广泛的在线教程、方案、核磁共振脉冲序列和其他技术材料的“知识库”来提供。任何机构的远程用户都可以携带或发送他们的样本，以利用NaN资源。对本科生和少数族裔服务机构的有针对性的扩展将促进更广泛地参与核磁共振研究社区。结合起来，增强的网络基础设施和新的仪器将有助于解决高场核磁共振能力方面的国家不足。培训和启用更多的研究人员和新的变革性研究将服务于NSF的任务重点，以推动所有科学和工程领域的发展。NaN将通过中心辐射式模式运行，该模式动态适应不断变化的社区需求。康涅狄格大学的这个中心将为美国研究人员访问最先进的核磁共振仪器、实验方案和专家提供便利。现有的网络基础设施将得到利用和扩展，以满足大量研究人员的存储、分析和数据重用需求。该项目还包括计划购买两台1.1 GHz核磁共振光谱仪，安装在南辐条地点。其中一个系统将安装在威斯康星大学进行固态核磁共振研究。第二个系统将安装在佐治亚大学，专门用于溶液核磁共振研究。随着NAN的扩展，将增加更多的地点，将更多的成员地点与美国现有的仪器结合在一起。将针对核磁共振技术的进步做出重大努力，包括改进光谱灵敏度、分辨率、松弛动力学、间接检测、采样、机器学习和其他方法。一旦建立，NAN将以分级支持水平运作，以支持和支持寻求使用新的1.1 GHz高场核磁共振系统或其他21种可在其他地点获得的核磁共振300-900 MHz仪器之一的美国研究人员。改进和分散利用这一庞大的核磁共振系统是NAN的一个主要好处。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

Nuclear magnetic resonance spectroscopy (NMR) is an essential tool for research into molecular structures and dynamics. This award will support the establishment of a geographically distributed Network for Advanced NMR (NAN) in the U.S. to provide ultra-high field NMR spectrometers to allow users to tackle important and diverse scientific problems and to educate and train the next generation of scientists and engineers. Scientific research areas enabled by these systems cover a wide range of problems in structural biology, dynamics and function of different biological systems from molecules to whole cells and tissues, complex mixtures, metabolomics, and natural products. Non-biological applications include, but are not limited to, amorphous materials, battery components, pharmaceutical ingredients, nanomaterials, surface coatings, and catalysts. User support and training will be provided through community outreach and an extensive “KnowledgeBase” of online tutorials, protocols, NMR pulse sequences, and additional technical materials. Remote users at any institution will be able to bring or send their samples to take advantage of NAN resources. Targeted outreach to undergraduate and minority serving institutions will promote broadening participation in the NMR research community. In combination, the enhanced cyberinfrastructure and new instruments will help to address a national deficit in high-field NMR capacity. Training and enabling more researchers and new transformative research will serve the NSF mission priority to advance all fields of science and engineering.The NAN will operate by a hub and spoke model that dynamically adapts to meet evolving community needs. The hub at the University of Connecticut will facilitate access to state-of-the-art NMR instrumentation, experimental protocols, and experts by US researchers. Existing cyberinfrastructure will be leveraged and expanded to serve the storage, analysis, and data-reuse needs for a large community of researchers. The project also includes plans to purchase two 1.1 GHz NMR spectrometers for installation at the NAN spoke locations. One system will be installed at University of Wisconsin for solid-state NMR research. The second system will be installed at the University of Georgia and be dedicated to solution NMR studies. Additional locations will be added as the NAN expands to incorporate more member locations with existing instrumentation in the U.S. Significant efforts will be directed toward the advancement of NMR technology, including improvements for spectral sensitivity, resolution, relaxation dynamics, indirect detection, sampling, machine learning and other methods. Once established, the NAN will operate with tiered support levels to both enable and support U.S. researchers seeking to use the new 1.1 Ghz high-field NMR systems or one of the 21 other NMR 300-900 MHz instruments available at other locations. Improved and distributed utilization of this large complement of NMR systems is a key benefit of the NAN.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.