MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer to Enhance Research and Training at Skidmore College

该奖项由主要研究仪器项目和化学研究仪器项目支持。斯基德莫尔学院正在购买一台配备自动换样器的400 MHz核磁共振(核磁共振)光谱仪，以支持Steven Frey教授及其同事Raymond Giguere、Juan Navea、Aurelia Ball和Anna Brezny。这种光谱仪允许在各种领域进行研究，例如那些加速具有重大经济意义的化学反应的领域，以及允许研究具有生物相关性的物种。总体而言，核磁共振波谱是化学家用于阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。该仪器是该机构和附近的纽约州立大学阿迪朗达克社区学院化学和生物化学本科生教学和研究培训不可或缺的一部分。授予核磁共振光谱仪旨在加强所有级别的研究和教育。这尤其影响了合成的锰(II)络合物作为超氧化物歧化酶模拟物的表征。该仪器还用于表征和调节小蛋白同源3(SH3)结构域结合途径的生物物理学。此外，它还有助于发展有机电化学的机理研究和探索以分子内环加成为重点的有机合成。该光谱仪还用于研究pH值在与大气相关的光敏剂的水溶液光化学中的作用。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Skidmore College is acquiring a 400 MHz nuclear magnetic resonance (NMR) spectrometer equipped with an automatic sample changer to support Professor Steven Frey and colleagues Raymond Giguere, Juan Navea, Aurelia Ball and Anna Brezny. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as permitting study of biologically relevant species. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate students in chemistry and biochemistry at this institution and at nearby State University of New York Adirondack Community College.The award of an NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts the characterization of synthesized manganese(II) complexes used as mimics for superoxide dismutase. The instrumentation is also used for characterizing and modulating the small protein homology 3 (SH3) domain binding pathway biophysics. In addition, it benefits the development of methodology for mechanistic studies in organic electrochemistry and for exploring organic synthesis focusing on intramolecular cycloadditions. The spectrometer is also used for studying the role of pH in the aqueous photochemistry of atmospherically-relevant photosensitizers.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.