MRI: The Acquisition of a Flow Cytometer to Enhance Research and Training at South Carolina Undergraduate Institutions in the Upstate

弗曼大学获得了一项奖励，以支持购置一台流式细胞仪，以加强南卡罗来纳州北部的研究和培训。流式细胞术是一种强大的工具，用于同时分析细胞内或类似大小的物体中的多种生物和/或化学靶标。它具有分析大型异质样本中罕见种群的速度、灵敏度和鲁棒性，使其成为福尔曼大学（一所研究活跃的本科大学）生物、化学和神经科学项目中以教师为主导、以学生为中心的重要分析工具。此外，其他地区pui的教师和学生的研究工作将受益于使用该设备。收购流式细胞仪将使三个参与机构每年至少50名学生和教师的高影响力参与。通过多个活跃的NSF夏季研究项目，来自地区PUIs、hbcu、两年制学院和第一代服务机构的更多教师和学生将直接受益于该仪器。教师主导的研究项目作为福尔曼从事学习的科学本科生的愿景的基石。获得流式细胞仪将使多种研究成为可能，包括(1)淋巴细胞谱系中激活诱导的染色质去浓缩；(2)聚二乙炔脂质体作为传感器和显像剂；(3)活性氧真菌的作用；(4)新型PI3K抑制剂的开发；(5)性别差异对高脂饮食的影响；(6) RNA结合蛋白；(7)干细胞生物学。教师致力于在全国会议和出版物上发表他们的研究成果，其中包括在受人尊敬的同行评审期刊上发表本科生合著者。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

An award is made to Furman University to support the acquisition of a flow cytometer to enhance research and training in the South Carolina Upstate. Flow cytometry is a powerful tool for the simultaneous analysis of multiple biological and/or chemical targets within cells or similarly sized objects. It possesses the speed, sensitivity, and robustness to analyze rare populations within large, heterogeneous samples, making it a critical analytical tool that will be used in faculty-led, student-centered research in the Biology, Chemistry, and Neuroscience programs at Furman, a research-active Primarily Undergraduate Institution (PUI). In addition, faculty and student research efforts at other regional PUIs will benefit from access to this equipment. Acquisition of the flow cytometer will enable the high-impact engagement of at least 50 students and faculty across the three participating institutions each year. Through multiple active NSF summer research programs, additional faculty and students from regional PUIs, HBCUs, two-year colleges, and first generation-serving institutions will directly benefit from access to the instrument. Faculty-led research programs serve as the cornerstone of Furman’s vision of engaged learning for undergraduates in the sciences. Acquisition of the flow cytometer will enable diverse research including (1) activation-induced chromatin decondensation in cells of the lymphocyte lineage; (2) polydiacetylene liposomes as sensors and imaging agents; (3) effects of reactive oxygen species fungi; (4) the development of novel PI3K inhibitors; (5) sex differences in the effects of high fat diet; (6) RNA binding proteins; and (7) stem cells biology. Faculty are committed to dissemination of their findings in presentations at national conferences and publications that include undergraduate co-authors in respected peer-reviewed journals.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.