The resting state of B lymphocytes and their Transition into early and late activation stages (02)

项目02研究静息B淋巴细胞表面受体的纳米级组织。我们发现，在这些细胞上，IgM和IgD类的B细胞抗原受体位于不同的受体纳米簇内，并且四跨膜蛋白CD 20是IgD类纳米结构域的关键守门人。在新的资助期内，我们希望更多地了解CD20的看门人功能，B细胞如何退出静息状态，并研究在没有CD20的情况下调节拉莫斯B细胞向浆细胞发育的关键调节回路。

The project 02 studies the nanoscale organization of receptors on the surface of resting B lymphocytes. We found that on these cells the B cell antigen receptors of class IgM and IgD are localized inside distinct receptor nanocluster and that the tetraspanning membrane protein CD20 is a critical gatekeeper for the IgD class nanodomain. In the new funding period, we want to learn more about the CD20 gatekeeper function, how B cells exit the resting state and study critical regulatory circuits that regulate the B-cell to plasma cell development of Ramos B cells without CD20.