Conference: Protein Folding on the Ribosome

2020年核糖体蛋白质折叠年会将于2020年12月11日至13日在马里兰州巴尔的摩的约翰霍普金斯大学举行。新生蛋白折叠、靶向和质量控制是确保细胞正常功能的关键。理解细胞中新生蛋白质折叠和行为提出了理论和实验上的挑战，这些挑战正在一个充满活力、多学科和不断发展的研究领域得到解决。这次会议将由一群国际科学家参加，并将促进新知识的共享，激发美国国内外新的合作研究努力。对研究生和博士后的旅行援助将促进未来STEM劳动力的培训，特别是通过与各学科专业的国际研究人员建立联系的机会。在过去的几十年里，关于基因组序列和它们编码的蛋白质结构的信息出现了爆炸式的增长。这两个领域的交集，即多肽是由核糖体合成的，目前还没有得到充分的研究。本次会议的重点将是新兴主题，包括新生多肽链的结构和折叠，翻译的调节，新生多肽链的靶向和转运到膜。总体目标将是：i)概述最近的进展并确定最紧迫的挑战；Ii)确定现有方法的局限性，并培养开发新方法的想法；促进实验、理论和计算研究人员之间的知识交流和合作。因此，这次会议将为科学家们提供一个平台，继续推进对蛋白质生物发生的不同方面的理解，以及它们如何使细胞功能和复杂性得以实现。本次会议由生物科学理事会分子和细胞生物科学部的分子生物物理学和遗传机制项目支持。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The 2020 Annual Meeting on Protein Folding on the Ribosome will be held at Johns Hopkins University in Baltimore, MD on December 11-13, 2020. Nascent protein folding, targeting and quality control are key to ensuring proper cellular function. Understanding nascent protein folding and behavior in cells presents theoretical and experimental challenges that are being tackled in a vibrant, multi-disciplinary and growing research arena. This meeting will be attended by an international cohort of scientists, and will promote sharing of new knowledge and stimulate new collaborative research efforts both within and outside of the US. Travel assistance to graduate students and postdocs will promote training of the future STEM workforce, notably through networking opportunities with international researchers specializing in a variety of disciplines.The past few decades have seen an explosive growth in information about genomic sequences and the structures of the proteins they encode. The intersection of these two realms, at which polypeptides are synthesized by the ribosome, is still comparatively poorly explored. The focus of this meeting will be on emergent topics, including nascent polypeptide chain structure and folding, regulation of translation, and nascent chain targeting and translocation to membranes. The overall goals will be to: i) provide an overview of recent progress and identify the most pressing challenges; ii) identify limitations of currently available methodologies and foster ideas for developing novel approaches; and iii) promote knowledge exchange and collaboration between and among experimental, theoretical and computational researchers. Thus, the meeting will serve as a platform for scientists to continue to advance understanding of different facets of protein biogenesis and how they enable cellular function and complexity.This meeting is supported by the Molecular Biophysics and the Genetic Mechanisms programs of the Division of Molecular and Cellular Biosciences in the Biological Sciences Directorate.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.