MRI: Acquisition of an NMR console and probe to support research and education
MRI: Acquisition of an NMR console and probe to support research and education
批准号:
2116395
负责人:
Robert Williamson
金额:
$50.0万
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-08-01 至 2024-07-31
中文摘要
该奖项由主要研究仪器项目和化学研究仪器项目支持。北卡罗来纳大学威尔明顿分校正在升级500 MHz核磁共振光谱仪控制台的电子设备,并为其配备现代探头,以支持威斯康星大学的化学研究。这种光谱仪允许在各种领域进行研究,例如那些加速具有重大经济意义的化学反应的领域,以及允许研究化学和生物相关的物种。总的来说,核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质,表征分子中原子的特定排列,并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说,获得最先进的核磁共振光谱仪是必不可少的。该仪器是该机构化学和生物化学专业的本科生以及地区学院的合作者(如北卡罗来纳大学彭布罗克分校的合作者)在教学、研究和研究培训中不可或缺的一部分,该学院服务于不同的学生群体。彭布罗克科学改进研究计划(RISE)的学生是该仪器的用户,他们的目标是创建更多样化的研究队伍。授予核磁共振光谱仪旨在加强各级的研究和教育。它尤其影响了促进中小分子结构阐明的方法学的发展。该仪器还用于研究化学生态学,并用于从结构上确定培养微生物和有害藻华的天然产物。该仪器还为评估药用植物提取物的研究人员提供服务。这一奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。
英文摘要
This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The University of North Carolina at Wilmington (UNCW) is upgrading the electronics of a console for a 500 MHz nuclear magnetic resonance (NMR) spectrometer and is equipping it with a modern probe to support chemistry research at UNCW. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as permitting study of chemically and biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate students in chemistry and biochemistry at this institution as well as collaborators from regional colleges such as those from the University of North Carolina at Pembroke that serves a distinctly diverse student body. Students from the Pembroke’s Research Initiative for Scientific Enhancement (RISE) Program whose goal is to create a more diverse research workforce are users of this instrumentation.The award of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts the development of methodologies to facilitate the structure elucidation of small and medium-sized molecules. The instrumentation is also used to study the chemical ecology and for structurally determining natural products from cultured microbes and harmful algal blooms. The instrument also serves researchers evaluating medicinal plant extracts.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
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Cannabicitran: Its unexpected racemic nature and potential origins
大麻素:其意想不到的外消旋性质和潜在起源
DOI:
10.1002/chir.23571
发表时间:
2023
期刊:
Chirality
影响因子:
2
作者:
[Wood, Jared S., Gordon, William H., Morgan, Jeremy B., Williamson, R. Thomas]
通讯作者:
Williamson, R. Thomas
Structural revision of a Wnt/β-catenin modulator and confirmation of cannabielsoin constitution and configuration
Wnt/β-连环蛋白调节剂的结构修订和大麻素组成和配置的确认
DOI:
10.1039/d1cc01971f
发表时间:
2021
期刊:
Chemical Communications
影响因子:
4.9
作者:
[Monroe, Angelina Z., Gordon, William H., Wood, Jared S., Martin, Gary E., Morgan, Jeremy B., Williamson, R. Thomas]
通讯作者:
Williamson, R. Thomas
DOI:
10.33697/ajur.2022.054
发表时间:
2022-06
期刊:
American journal of undergraduate research
影响因子:
--
作者:
[Edwards, Ashley, Deberry, Kazhmiri, Mariani, Hannah, Taylor, Darian H, Cochran, Nicholas J, Barrios Sosa, Ana C, Scott, Andrea Regan, Williamson, R Thomas, Tirla, Cornelia, Sandefur, Conner, Alexander, Courtney Carroll]
通讯作者:
Alexander, Courtney Carroll
Prediction of anisotropic NMR data without knowledge of alignment medium structure by surface decomposition
在不了解排列介质结构的情况下通过表面分解预测各向异性 NMR 数据
DOI:
10.1039/d2cp02621j
发表时间:
2022
期刊:
Physical Chemistry Chemical Physics
影响因子:
3.3
作者:
[Liu, Yizhou, Ndukwe, Ikenna E., Reibarkh, Mikhail, Martin, Gary E., Williamson, R. Thomas]
通讯作者:
Williamson, R. Thomas
Calculated and experimental 1 H and 13 C NMR assignments for cannabicitran
大麻素的计算和实验 1 H 和 13 C NMR 归属
DOI:
10.1002/mrc.5224
发表时间:
2021
期刊:
Magnetic Resonance in Chemistry
影响因子:
2
作者:
[Wood, Jared S., Gordon, William H., Morgan, Jeremy B., Williamson, R. Thomas]
通讯作者:
Williamson, R. Thomas
共 6 条
Expansion of the MCRI Microarray Facility
-
批准号:nhmrc : 221499
-
项目类别:NHMRC Block Funding
-
资助金额:$25.56万
-
财政年份:2002
-
负责人:Robert Williamson
-
依托单位:
Murdoch Childrens Research Institute Transitional Block Grant
-
批准号:nhmrc : 222095
-
项目类别:NHMRC Block Funding
-
资助金额:$90.19万
-
财政年份:2002
-
负责人:Robert Williamson
-
依托单位:
Uncoupled Research Fellowship
-
批准号:nhmrc : 216727
-
项目类别:NHMRC Research Fellowships
-
资助金额:$11.61万
-
财政年份:2001
-
负责人:Robert Williamson
-
依托单位:
Murdoch Institute
-
批准号:nhmrc : 973051
-
项目类别:NHMRC Block Funding
-
资助金额:$410.63万
-
财政年份:1997
-
负责人:Robert Williamson
-
依托单位:
Physics Demonstrations and Equipment
-
批准号:8470359
-
项目类别:Standard Grant
-
资助金额:$7.52万
-
财政年份:1984
-
负责人:Robert Williamson
-
依托单位:
Fire Safety in Urban Housing
-
批准号:7604824
-
项目类别:Standard Grant
-
资助金额:$26.1万
-
财政年份:1975
-
负责人:Robert Williamson
-
依托单位:
Fire Safety in Urban Housing
-
批准号:7001080
-
项目类别:Standard Grant
-
资助金额:$66.56万
-
财政年份:1971
-
负责人:Robert Williamson
-
依托单位:
海外基金