PFI TT: A hand-held device for rapid and accurate determination of cancerous tumor margins during surgical resections

创新伙伴关系-技术转化（PFI-TT）项目的更广泛影响/商业潜力改善了癌症患者的预后。这项提议的研究将开发一种手持设备，帮助外科医生在手术过程中快速准确地确定肿瘤周围的边缘区域。正确的肿瘤切除（称为切除）减少了手术时间、恢复时间和后续手术的风险。拟议的技术将降低成本并改善结果。该项目将展示一种手持式传感器设备，该设备可以在手术过程中快速准确地确定肿瘤周围的切除区域。确定和验证切除周长可能具有挑战性，并且不准确的肿瘤边缘确定可能导致后续手术。该研究将探讨：1)快速、准确和一致地测量羟基自由基作为活性肿瘤生长的生物标志物；2)羟基自由基浓度与癌症进展阶段之间的关系。该项目将设计和优化传感器尖端和电极的组成和几何形状，以最大限度地减少噪音；它将通过使用具有不同羟基自由基水平的三维球体基质的体外测试进一步验证数据。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) project improves outcomes for cancer patients. The proposed research will develop a hand-held device that helps surgeons rapidly and accurately determine the marginal areas around the tumor during surgery. Correct tumor removal (known as resection) reduces the surgical time, the recovery time, and the risk of subsequent surgeries. The proposed technology will reduce cost and improve outcomes. The proposed project will demonstrate a hand-held sensor device that rapidly and accurately determines the resection area around a tumor during surgery. Identifying and verifying the resection perimeter can be challenging, and inaccurate determination of tumor margins can lead to subsequent surgeries. The proposed research will investigate: 1) rapid, accurate and consistent measurement of hydroxyl radicals as a biomarker for active tumor growth, and 2) the relationship between hydroxyl radical concentrations and the cancer stage of progression. The project will design and optimize the sensor tip and electrode composition and geometry to minimize noise; it will further validate the data with in vitro tests using 3-D spheroids matrixes with varying hydroxyl radical levels.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.