Tunable Catalysts Based on Low Valent Metal-Phosphine Framework Materials

在化学系化学催化项目的支持下，圣地亚哥加州大学的Seth Cohen教授正在研究一类新型固体可调催化材料的开发。使用与钯，铑和铱金属中心连接的磷衍生配体的组合，科恩教授和他的研究团队将创建具有催化潜力的新分子框架。正在探索对这些材料的修改，以确定如何调整它们以促进交叉偶联和加氢反应（一氧化碳捕获和掺入有用的结构单元），这对于精细化学品，药物和其他重要产品的制造非常重要。除了这些研究之外，科恩教授还支持加州大学系统的本科生前往华盛顿特区，在那里他们可以通过科学政策实习计划（SPIP）参与公共政策和科学的实习，同时还开设了一门本科生科学政策课程。创新的催化材料对于满足新化学反应的需求至关重要生产精细化学品、药品和其他重要产品。该研究计划正在开发一类新的固态催化剂，用于进行高价值的化学转化。具体而言，正在研究来源于基于磷的配体框架和低氧化态反应性金属的金属有机框架（MOF，一种多孔固体）。使用低氧化态金属作为MOFs的组分是不常见的和不发达的，但是对于C-C键形成反应是潜在有价值的。 MOF催化剂的有机和金属组分都将以模块化的方式进行检查，以研究结构-功能关系，优化催化活性，并探索选择性的机会。 这些研究旨在确定如何低氧化态，框架材料可以作为模块化，下一代，固态催化剂。协同作用，这些活动将促进研究生和本科生的多元化群体的培训，同时也支持本科生参与科学政策实习计划，并通过课程开发扩大科学政策讨论。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

With the support of the Chemical Catalysis Program in the Division of Chemistry, Professor Seth Cohen of the University of California, San Diego is studying the development of a new class of solid, tunable catalytic materials. Using a combination of phosphorus-derived ligands linked to palladium, rhodium, and iridium metal centers, Professor Cohen and his research team will create new molecular frameworks with potential for catalysis. Modifications to these materials are being explored to determine how to tune them to promote cross-coupling and hydroformylation reactions (carbon monoxide capture and incorporation into useful building blocks) that are important for the manufacture of fine chemicals, pharmaceuticals, and other important products. In addition to these studies, Professor Cohen is supporting undergraduate students from across the University of California system to travel to Washington DC where they can participate in internships at the interface of public policy and science through the Science Policy Internship Program (SPIP), and is simultaneously creating an undergraduate scientific policy course.Innovative catalytic materials are essential to keep up with demand for new chemical reactions that produce fine chemicals, pharmaceuticals, and other important products. This research program is developing a new class of solid-state catalysts for performing high-value chemical transformations. Specifically, metal-organic frameworks (MOFs, a type of porous solid) derived from phosphorus-based ligand frameworks and low oxidation state reactive metals are being investigated. The use of low oxidation state metals as a component of MOFs is uncommon and underdeveloped, but potentially valuable for C-C bond forming reactions. Both the organic and metal component of the MOF catalysts will be examined in a modular manner, to investigate structure-function relationships, optimize catalytic activity, and explore opportunities for selectivity. These studies are designed to determine how low oxidation state, framework materials can serve as modular, next-generation, solid state catalysts. Synergistically, these activities will promote the training of a diverse group of graduate and undergraduate students, while also supporting science policy internship program participation for undergraduates and broadening scientific policy discussion through course development.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.