Lanthanide Ion Complexes with Viscosity- or Temperature-dependent Emission

在这个由美国国家科学基金会化学分部化学结构、动力学与机制B和化学测量与成像项目资助的项目中，内华达大学里诺分校的Ana de Bettencourt-Dias教授和她的研究小组将分离出能够以金属为中心发光的镧系离子复合物。他们计划证明这种光发射可以被粘度和温度调制，他们将研究最能实现这种调制的化合物设计特征。有了将发射光的强度与温度和粘度联系起来的能力，该小组将能够测量细胞内部的温度和粘度。这些特性随细胞类型的不同而变化，是帮助疾病诊断和细胞代谢分解的重要特性。该研究还对工业过程的管理感兴趣，例如监测聚合和氢化过程的完成。在项目期间，本科生和研究生以及博士后学者将接受合成和光谱技术方面的培训，以成功完成拟议的工作。作为支持代表性不足的少数族裔教师的进步和包容性承诺的一部分，安娜·德·贝当古-迪亚斯教授将继续指导初级同事，并通过各种途径促进他们的科学，包括但不限于元素周期表讲座。镧系离子表现出明显的发射谱线。这种由4f轨道内的跃迁引起的发射，通过配体发色团最有效地敏化。这些发色团可以设计成显示能量转移到发射镧系离子，这是由粘度和温度调节。在这个项目中，Ana de Bettencourt-Dias教授和她的研究小组提出分离几种基于n -杂环和氰乙烯基分子转子的新配体，并评估它们促进金属离子中心发射的能力作为介质温度和粘度的函数。此外，他们将研究，通过使用异位络合物，配体官能使粘度和温度依赖的发射通过双光子激发过程。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

In this project, funded by the Chemical Structure, Dynamics & Mechanisms B and the Chemical Measurement and Imaging Programs of the Chemistry Division of the National Science Foundation, Professor Ana de Bettencourt-Dias and her research group at the University of Nevada, Reno, will isolate lanthanide ion complexes capable of metal-centered light emission. They plan to demonstrate that this light emission can be modulated by viscosity and temperature and they will study the compound design features that best enable this modulation. With the ability to correlate the intensity of the emitted light with the temperature and the viscosity, the group will be able to measure the temperature and viscosity inside of the cells. These properties vary with the type of cell and are important properties to help in the diagnosis of disease and in the unraveling of cell metabolism. The research is also of interest in the management of industrial processes, such as monitoring completion of polymerization and hydrogelation processes. During the project, undergraduate and graduate students as well as postdoctoral scholars will be trained in the synthesis and spectroscopic techniques needed to successfully complete the proposed work. As part of the commitment to support the advancement and inclusivity of underrepresented minority faculty, Professor Ana de Bettencourt-Dias will continue mentoring junior colleagues and promoting their science through a variety of avenues, including, but not limited to, the Periodic TableTalks. Lanthanide ions display sharp emission profile. This emission, which arises from transitions within the 4f orbitals, is most efficiently sensitized through coordinated ligand chromophores. These chromophores can be designed to display an energy transfer to the emissive lanthanide ion, which is modulated by viscosity and temperature. In this project, Professor Ana de Bettencourt-Dias and her research group propose to isolate several new ligands, based on N-heterocycles and cyanovinyl molecular rotors, and to assess their ability to promote metal-ion centered emission as a function of the temperature and viscosity of the medium. In addition, they will study, by using heteroleptic complexes, which ligand functionalities enable the viscosity- and temperature-dependent emission through a two-photon excitation process.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.