MRI: Acquisition of 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer Console and Probe to Bolster Excellence in Undergraduate Research

该奖项由主要研究仪器项目和化学研究仪器项目共同支持。罗兹学院正在为一台带有宽带探头的400 MHz核磁共振光谱仪购买升级版的控制台，以支持拉里·彼得森教授和他的同事威廉·R·埃肯霍夫的研究。该仪器促进了有机、生物有机和无机化学领域的研究。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。该工具加强了罗兹学院各级学生的教育、研究和教学努力，并为勒莫因-欧文学院的使用提供了便利。这一工具加强了这些机构中任职人数不足的群体的招聘和参与研究和教学工作。核磁共振光谱仪的获奖旨在加强各级的研究和教育，特别是在有机、生物有机和无机小分子研究方面。该仪器影响了各种研究项目，包括开发具有丰富稀土金属的高活性质子还原催化剂，以及设计和合成多巴胺衍生物和其他儿茶酚作为酶功能的探针。它还有助于动物毒液抗菌肽的合成、表征和生物活性研究，以及合成新的非天然氨基酸和突变多肽以确定FNII和CTLD1结构域。此外，该仪器还有助于设计LpxC酶的抑制剂、将芳基酮氧化为羧酸的新方法、合成琥珀酰苯胺异羟肟酸的硼酸类似物(SAHA)，以及为有机化学实验室发展基于课程的本科生研究经验。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Rhodes College is acquiring an upgraded console for a 400 MHz nuclear magnetic resonance (NMR) spectrometer with a broadband probe to support the research of Professor Larryn Peterson and colleague William R. Eckenhoff. This instrument facilitates research in the areas of organic, bioorganic, and inorganic chemistry. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument enhances the educational, research, and teaching efforts of students at all levels at Rhodes College as well as provides accessibility for use at LeMoyne-Owen College. This instrument enhances the recruitment and engagement in research and teaching for underrepresented groups at these institutions. The award of the NMR spectrometer is aimed at enhancing the research and education at all levels, especially in organic, bioorganic, and inorganic small molecule research. The instrument impacts a variety of research projects including the development of highly active proton reduction catalysts with earth abundant metals and the design and synthesis of dopamine derivatives and other catechols as probes for enzyme function. It also assists with the synthesis, characterization, and biological activity studies of antimicrobial peptides from animal venoms, and the synthesis of novel unnatural amino acids and mutated peptides to determine FNII and CTLD1 domains. Additionally, the instrument facilitates the design of inhibitors of the LpxC enzyme, new methods to oxidize aryl ketones to carboxylic acids, the synthesis of boronic acid analogues of suberoylanilide hydroxamic acid (SAHA), and the development of course-based undergraduate research experiences for the organic chemistry laboratory.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.