REU Site: A Cyberlinked Program in Computational Biomolecular Structure & Design

REU网站授予位于马里兰州巴尔的摩市的约翰霍普金斯大学，将在2023年至2025年的每个夏季为12名实习生提供为期10周的培训。研究是在位于美国和国外的罗塞塔公地的各个实验室进行的。预计总共有36名学生将接受该项目的培训，这些学生主要来自研究机会有限的学校或代表性不足的群体。学生将学习如何进行跨学科的合作研究，并在科学会议上展示他们的工作。完成REU课程后，学生将了解如何从结构角度调查生物学问题；有丰富的计算分子设计经验，包括人工智能方法；在生物化学，生物物理学，计算生物学，机器学习和分子工程的研究方法方面获得了坚实的基础；获得与全球其他实验室的其他科学家和工程师合作的技能；并且对这些领域的改进技术对社会的贡献有了更深的认识。该计划将使用在线SALG URSSA工具进行评估。NSF ETAP系统将用于登记参与者（https://www.nsfetap.gov/）。课程结束后，将对学生进行跟踪，以确定他们的职业道路。该研究使用计算方法来预测生物分子的结构（这是它们的行为和功能的基础）和设计新的生物分子（对材料、纳米技术和生物技术很重要）。研究项目包括“通过深度学习的抗体工程”、“使用生成方法的蛋白质设计”和“从头开始的蛋白质控制生物信号的计算设计”。该培训计划包括为期一周的训练营，学生们在那里学习计算机编码和结构生物学，在分布在美国和国外的实验室进行为期八周的研究，最后一周在一年一度的罗塞塔会议上聚在一起。在研究期间，学生将在主办实验室的指导下完成一个独立的研究项目，参加每周的虚拟期刊俱乐部，准备研究提案，并准备在会议上展示的海报。所有参与者完成负责任的研究行为课程。REU申请由招生委员会审查和选择，该委员会由所有职业水平的罗塞塔公共资源成员组成。有关该计划的更多信息，请访问www.rosettacommons.org/intern，或联系PI （Jeffrey J. Gray博士，jgray@jhu.edu）或项目管理员（Camille Mathis女士，cmathis@jhu.edu）。该奖项反映了美国国家科学基金会的法定使命，并通过基金会的智力价值和更广泛的影响审查标准进行评估，认为值得支持。

This REU Site award to Johns Hopkins University, located in Baltimore, MD, will support the training of 12 interns for 10 weeks during each summer from 2023 to 2025. Research is conducted in various labs of the Rosetta Commons located throughout the United States and abroad. It is anticipated that a total of 36 students, primarily from schools with limited research opportunities or from an under-represented group, will be trained in the program. Students will learn how interdisciplinary, collaborative research is conducted, and all will present their work at scientific conferences. Upon completion of the REU program, students will have gained an understanding of how to investigate biological problems from a structural perspective; experienced computational molecular design including artificial intelligence approaches; acquired a solid foundation in research methodologies in biochemistry, biophysics, computational biology, machine learning, and molecular engineering; gained skills to collaborate with other scientists and engineers in other laboratories globally; and gained a deeper appreciation for the contributions that improved technology in these areas can make to society. The program will be assessed using the online SALG URSSA tool. The NSF ETAP system will be used to register participants (https://www.nsfetap.gov/). Students will be tracked after the program to determine their career paths. The research uses computational methods for prediction of the structure of biomolecules (which underlies their behavior and function) and the design of new biomolecules (important for materials, nanotechnology, and biotechnology). Example research projects include “Antibody engineering by deep learning,” “Protein design using generative methods,” and “Computational design of de novo proteins to control biological signaling.” The training program consists of a one-week bootcamp where students learn computer coding and structural biology, eight weeks of research in distributed labs (across the US and abroad), and a final week together at the annual Rosetta Conference. During the research period, students will complete an independent research project under the mentorship of a host lab, participate in weekly virtual journal clubs, prepare research proposals, and prepare a poster for presentation at the conference. All participants complete the Responsible Conduct of Research course. REU applications are reviewed and chosen by an admissions committee consisting of Rosetta Commons members at all career levels. More information about the program is available by visiting www.rosettacommons.org/intern, or by contacting the PI (Dr. Jeffrey J. Gray at jgray@jhu.edu) or the program administrator (Ms. Camille Mathis at cmathis@jhu.edu).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.