Structural and pharmaceutical studies on a novel human protein, MIC-1

癌症和肥胖是澳大利亚面临的两个主要健康问题，国家研究优先事项：促进和保持良好健康反映了这一点。该项目将利用MIC-1蛋白开发新的癌症早期检测和预后诊断工具。MIC-1是恶病质的罪魁祸首，恶病质是一种消耗性疾病，导致25%的癌症死亡，目前还没有有效的治疗方法。MIC-1和中和MIC-1的抗体可能会提供治疗药物来控制癌症恶病质和严重肥胖。该项目将优化这些分子用于治疗用途。这些诊断和治疗工具将形成一个商业化的分拆公司的基础。

Cancer and obesity are two of the main health problems facing Australia, as reflected by the National Research Priority: Promoting and Maintaining Good Health. This project will develop new diagnostic tools for early cancer detection and prognosis using the protein, MIC-1. MIC-1 is responsible for cachexia, a wasting disorder responsible for 25% of cancer deaths, which has no effective therapy. MIC-1 and antibodies neutralising MIC-1 may provide therapeutic agents to control cancer cachexia and severe obesity. The project will optimise these molecules for therapeutic uses. These diagnostic and therapeutic tools will form the basis of a spin-off company for commercialisation.