X-ray facility for protein crystallography

用于蛋白质晶体学的 X 射线设备

• 批准号: LE190100165
• 负责人: Prof Paul Curmi
• 金额: $ 27.18万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE190100165
• 关键词: ray; facility; protein; crystallography

This project aims to establish an X-ray crystallography facility to enhance the productivity of structural biology.. The facility will increase the speed and success rate for protein structure determination. It is expected to produce protein crystals, optimise them for X-ray diffraction quality and determine initial structures prior to ultimate analysis at the Australian Synchrotron for maximal resolution. The goal of this facility is to accelerate the rate of macromolecular structure determination, which will provide the basis for the future development of biotechnology and biopharmaceuticals. The resulting protein structures will enhance research in molecular and cell biology, synthetic biology and chemistry, biochemistry and the design of inhibitors for biotechnology and biopharmaceuticals.

该项目旨在建立一个X射线晶体学设施，以提高结构生物学的生产力。该设施将提高蛋白质结构测定的速度和成功率。预计它将生产蛋白质晶体，优化它们的X射线衍射质量，并在澳大利亚同步加速器进行最终分析之前确定初始结构，以获得最大分辨率。该设施的目标是加快大分子结构测定的速度，这将为生物技术和生物制药的未来发展提供基础。由此产生的蛋白质结构将加强分子和细胞生物学、合成生物学和化学、生物化学以及生物技术和生物制药抑制剂设计方面的研究。