1. Total Synthesis of Vinigrol Using a New Strategic Concept,2. Asymmetric Alkynyl-Substituted Trimethylenemethane [6+3] Cycloadditions,3. Total Synthesis of Bryostatin 3 Using a New Strategic Concept

综上所述，我们设想了一个Trost不对称的PD-TMM反应，然后是一个新的扩环过程，作为提供一条合成天然产物--乙烯基酚的有效途径的关键步骤。此外，我们的合成计划将研究一类重要的电环反应的范围，即与新型TMM供体(三亚甲基甲烷衍生物)和受体的[6+3]环加成反应，这些反应以前没有被测试过，从而扩大了不对称PD-TMM反应的范围。这将为更直接地合成含有双环核心结构的生物活性分子铺平道路。这种新的合成涉及一种前所未有的战略类型，也将提供容易地制造现有路线所不能获得的类似物的前景。

In summary, we envisage a Trost asymmetric Pd-TMM reaction followed by a novel ring expansion process as the key steps to provide an efficient route to a natural product - vinigrol. Additionally, our synthetic program will examine the scope of an important class of electrocyclic reactions, namely [6+3] cycloaddition with novel TMM donors (trimethylenemethane derivatives) and acceptors, which have not been tested previously, expanding the scope of asymmetric Pd-TMM reactions. This will pave the way to a more straightforward syntheses of bioactive molecules containing bicyclic core structures. This new synthesis involving an unprecedented type of strategy will also offer the prospect of easily making analogues not available by the existing routes.