New methods for the synthesis of stable cyclic peptides

该提案将设计、合成和评估新型环肽碳环类似物，这些类似物可应用于疼痛治疗、糖尿病管理、疟疾以及癌症治疗和诊断。碳环类似物将具有改善的生物稳定性，并且还将提供口服给药的机会。 胰岛素的碳环类似物可能会改善澳大利亚120万糖尿病患者的治疗，其中包括许多特别容易患II型糖尿病及其衰弱并发症的澳大利亚土著人。

This proposal will design, synthesise and evaluate novel carbocyclic analogues of cyclic peptides which have application in the treatment of pain, diabetes management, malaria, and cancer therapy and diagnosis. The carbocyclic analogues will have improved biostability and will also provide the opportunity for oral administration. Carbacyclic analogues of insulin could lead to improved treatment of Australia's 1.2 million diabetics including many Aboriginal Australians who are particularly susceptible to Type II diabetes and its debilitating complications.