Is Syndecan-1 the mediator of the fine regulation of embryonic invasion depth by means of apoptosis and the related decision on regular or pathological implantation in humans and mice?

在该项目中，代表了胚胎植入母体子宫内膜，作为怀孕过程中的一个接口，应该进行检查。胎盘对母体子宫内膜间质的侵袭深度至关重要。浅着床意义上的侵袭性太低，会导致孕期母婴患上危及生命的疾病。同样危险的是过度侵入，这可能会导致胎盘脱离问题，可能导致在分娩期间和之后出现危及生命的情况。一项研究表明，事实上，60%的怀孕早期以及大多数未被发现的临床前阶段的受孕没有正确发育，植入控制往往没有正确进行。由于到目前为止，充分的胎盘放置和植入的操作还不完全清楚，所以在这里应该研究确切的侵袭深度调节的细胞机制。因此，如何创造胚胎在母体组织中适当植入所需的空间，以及如何正确调节侵袭深度的问题应该得到回答。趋化因子受体Syndecan-1似乎在胚胎着床过程中发挥作用，特别是在细胞凋亡的调节中。在这里，将阐明Syndecan-1利用哪些信号通路来诱导细胞凋亡，以及它如何调节胚胎的侵袭深度，以促进适当的着床。此外，还应研究Syndecan-1表达异常是否会引发妊娠障碍和胚胎代谢变化。自噬和缺氧的作用以及它们对细胞凋亡的影响，从而对胚胎侵袭深度的调节也应该进一步确定。

Within the project represented the embryonic implantation into the maternal endometrium as an interface on the course of pregnancy is supposed to be examined . The invasion depth of the conceptus into the maternal endometrial stroma is of paramount importance. Too low invasion in the sense of "shallow implantation" can lead to life-threatening diseases of mother and child during pregnancy. Equally dangerous is an excessive invasion, which can cause placenta detachment problems possibly leading to life-threatening situations during and after child birth. That the control of implantation is often not carried out correctly describes a study showing that in fact 60% of conceptions in the early and mostly undiscovered pre-clinical stages of pregnancy do not develop correctly. Since the operation of an adequate placentation and implantation are not fully understood so far, the cellular mechanisms underlying the regulation of the exact depth of invasion shall be investigated herein. Therefore, the question of how the space needed for a proper implantation of the embryo in the maternal tissue is created and how the correct regulation of invasion depth is orchestered is supposed to be answered . The chemokine receptor Syndecan-1 appears to play a role in the course of embryonic implantation, especially in the mediation of apoptosis. Herein it will be clarified which signaling pathways Syndecan-1 utilizes to induce apoptosis and how it regulates therewith the invasion depth of the conceptus to facilitate a proper implantation. Furthermore, it should be investigated, whether a dysregulated Syndecan-1 expression may provoke the onset of pregnancy disorders and metabolic changes of the embryos. The role of autophagy and hypoxia and their influence on apoptosis and thus regulation of embryonic invasion depth should also be further identified.